Prognostic impact of mechanical ventilation after liver transplantation: A national database study

Hui Yuan; Janet E. Tuttle-Newhall; Vikram Chawa; Mark A. Schnitzler; Huiling Xiao; David Axelrod; Nino Dzebisashvili; Krista L. Lentine

doi:10.1016/j.amjsurg.2014.06.004

Prognostic impact of mechanical ventilation after liver transplantation: A national database study

Hui Yuan, Janet E. Tuttle-Newhall, Vikram Chawa, Mark A. Schnitzler, Huiling Xiao, David Axelrod, Nino Dzebisashvili, Krista L. Lentine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Background

Methods:

Results: Among 10,517 LT recipients, 6.9% (n = 726) required postoperative MCVS, 25.6% of whom required less than 96 hours, 24.2% required 96 hours or longer, and 50.1% received an unspecified duration. Significant predictors of prolonged MCVS included older age, female sex, pretransplant dialysis requirement, and ascites. After multivariate adjustment, MCVS of 96 hours or longer was associated with nearly 3 times the adjusted hazard ratio of mortality (2.95, P <.001), while MCVS less than 96 hours was not significantly associated with mortality (adjusted hazard ratio.88, P =.55)

Conclusions: Recognition of LT patients at risk for prolonged MCVS may help to reduce the incidence and consequences of this complication.

Original language	English (US)
Pages (from-to)	582-590
Number of pages	9
Journal	American Journal of Surgery
Volume	208
Issue number	4
DOIs	https://doi.org/10.1016/j.amjsurg.2014.06.004
State	Published - Oct 1 2014

Keywords

Graft failure
Liver transplantation
Mechanical ventilation
Medicare
Mortality

ASJC Scopus subject areas

Surgery

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10.1016/j.amjsurg.2014.06.004

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@article{22452dded249405db88a2cecd0da2c4a,

title = "Prognostic impact of mechanical ventilation after liver transplantation: A national database study",

abstract = "BackgroundMethods:Results: Among 10,517 LT recipients, 6.9\% (n = 726) required postoperative MCVS, 25.6\% of whom required less than 96 hours, 24.2\% required 96 hours or longer, and 50.1\% received an unspecified duration. Significant predictors of prolonged MCVS included older age, female sex, pretransplant dialysis requirement, and ascites. After multivariate adjustment, MCVS of 96 hours or longer was associated with nearly 3 times the adjusted hazard ratio of mortality (2.95, P <.001), while MCVS less than 96 hours was not significantly associated with mortality (adjusted hazard ratio.88, P =.55)Conclusions: Recognition of LT patients at risk for prolonged MCVS may help to reduce the incidence and consequences of this complication.",

keywords = "Graft failure, Liver transplantation, Mechanical ventilation, Medicare, Mortality",

author = "Hui Yuan and Tuttle-Newhall, \{Janet E.\} and Vikram Chawa and Schnitzler, \{Mark A.\} and Huiling Xiao and David Axelrod and Nino Dzebisashvili and Lentine, \{Krista L.\}",

note = "Funding Information: This work was supported in part by grants from the National Institutes of Health / National Institute of Diabetes and Digestive and Kidney Diseases RC1DK086450 . Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

month = oct,

day = "1",

doi = "10.1016/j.amjsurg.2014.06.004",

language = "English (US)",

volume = "208",

pages = "582--590",

journal = "American Journal of Surgery",

issn = "0002-9610",

publisher = "Elsevier",

number = "4",

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TY - JOUR

T1 - Prognostic impact of mechanical ventilation after liver transplantation

T2 - A national database study

AU - Yuan, Hui

AU - Tuttle-Newhall, Janet E.

AU - Chawa, Vikram

AU - Schnitzler, Mark A.

AU - Xiao, Huiling

AU - Axelrod, David

AU - Dzebisashvili, Nino

AU - Lentine, Krista L.

N1 - Funding Information: This work was supported in part by grants from the National Institutes of Health / National Institute of Diabetes and Digestive and Kidney Diseases RC1DK086450 . Publisher Copyright: © 2014 Elsevier Inc.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - BackgroundMethods:Results: Among 10,517 LT recipients, 6.9% (n = 726) required postoperative MCVS, 25.6% of whom required less than 96 hours, 24.2% required 96 hours or longer, and 50.1% received an unspecified duration. Significant predictors of prolonged MCVS included older age, female sex, pretransplant dialysis requirement, and ascites. After multivariate adjustment, MCVS of 96 hours or longer was associated with nearly 3 times the adjusted hazard ratio of mortality (2.95, P <.001), while MCVS less than 96 hours was not significantly associated with mortality (adjusted hazard ratio.88, P =.55)Conclusions: Recognition of LT patients at risk for prolonged MCVS may help to reduce the incidence and consequences of this complication.

AB - BackgroundMethods:Results: Among 10,517 LT recipients, 6.9% (n = 726) required postoperative MCVS, 25.6% of whom required less than 96 hours, 24.2% required 96 hours or longer, and 50.1% received an unspecified duration. Significant predictors of prolonged MCVS included older age, female sex, pretransplant dialysis requirement, and ascites. After multivariate adjustment, MCVS of 96 hours or longer was associated with nearly 3 times the adjusted hazard ratio of mortality (2.95, P <.001), while MCVS less than 96 hours was not significantly associated with mortality (adjusted hazard ratio.88, P =.55)Conclusions: Recognition of LT patients at risk for prolonged MCVS may help to reduce the incidence and consequences of this complication.

KW - Graft failure

KW - Liver transplantation

KW - Mechanical ventilation

KW - Medicare

KW - Mortality

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DO - 10.1016/j.amjsurg.2014.06.004

M3 - Article

C2 - 25151187

AN - SCOPUS:84908156029

SN - 0002-9610

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SP - 582

EP - 590

JO - American Journal of Surgery

JF - American Journal of Surgery

IS - 4

ER -

Prognostic impact of mechanical ventilation after liver transplantation: A national database study

Abstract

Keywords

ASJC Scopus subject areas

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