Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity

Ashley C. Mays, Ehab Y. Hanna, Renata Ferrarotto, Jack Phan, Diana Bell, Natalie Silver, Collin F. Mulcahy, Dianna Roberts, Ahmed Salama Ahmed Abdelmeguid, Clifton D. Fuller, Steven J. Frank, Shaan M. Raza, Michael E. Kupferman, Franco DeMonte, Shirley Y. Su

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: Optimal treatment and prognostic factors affecting long-term survival in patients with sinonasal adenoid cystic carcinoma (ACC) have yet to be clearly defined. Methods: We conducted a retrospective review of patients treated with curative intent from 1980-2015 at MD Anderson Cancer Center. Results: One hundred sixty patients met inclusion criteria, including 8 who were treated with radiotherapy alone. Median follow-up time was 55 months. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 67.0% and 49.0%, respectively. The 10-year OS and DFS rates were 44.8% and 25.4%, respectively. Factors that portended for poor survival on multivariate analysis were recurrent disease, any solid type histology, epicenter in the sinus cavity, the presence of facial symptoms, or the original disease not treated with surgery. There was no association between surgical margin status or nodal status and survival. Conclusion: In this large cohort of patients with sinonasal ACC with extended follow-up, long-term survival is better than reported in prior literature. Future research should target patients with adverse risk factors.

Original languageEnglish (US)
Pages (from-to)2596-2605
Number of pages10
JournalHead and Neck
Volume40
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • adenoid cystic carcinoma
  • perineural invasion
  • prognostic factors
  • sinonasal tumor
  • skull base surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

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