Progesterone receptor-estrogen receptor crosstalk: A novel insight

Christoforos Thomas; Jan Åke Gustafsson

doi:10.1016/j.tem.2015.08.002

Progesterone receptor-estrogen receptor crosstalk: A novel insight

Christoforos Thomas, Jan Åke Gustafsson

Houston Methodist

Research output: Contribution to journal › Short survey › peer-review

30 Scopus citations

Abstract

Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.

Original language	English (US)
Pages (from-to)	453-454
Number of pages	2
Journal	Trends in Endocrinology and Metabolism
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/j.tem.2015.08.002
State	Published - Sep 1 2015

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Divisions

Medical Oncology

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10.1016/j.tem.2015.08.002

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title = "Progesterone receptor-estrogen receptor crosstalk: A novel insight",

abstract = "Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.",

author = "Christoforos Thomas and Gustafsson, \{Jan {\AA}ke\}",

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year = "2015",

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doi = "10.1016/j.tem.2015.08.002",

language = "English (US)",

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T2 - A novel insight

AU - Thomas, Christoforos

AU - Gustafsson, Jan Åke

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N2 - Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.

AB - Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.

UR - https://www.scopus.com/pages/publications/84940450337

UR - https://www.scopus.com/inward/citedby.url?scp=84940450337&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2015.08.002

DO - 10.1016/j.tem.2015.08.002

M3 - Short survey

C2 - 26277479

AN - SCOPUS:84940450337

SN - 1043-2760

VL - 26

SP - 453

EP - 454

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 9

ER -

Progesterone receptor-estrogen receptor crosstalk: A novel insight

Abstract

ASJC Scopus subject areas

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