Progesterone receptor-estrogen receptor crosstalk: A novel insight

Christoforos Thomas, Jan Åke Gustafsson

Research output: Contribution to journalShort surveypeer-review

17 Scopus citations

Abstract

Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.

Original languageEnglish (US)
Pages (from-to)453-454
Number of pages2
JournalTrends in Endocrinology and Metabolism
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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