Progesterone receptor-estrogen receptor crosstalk: A novel insight

Christoforos Thomas, Jan Åke Gustafsson

Research output: Contribution to journalShort surveypeer-review

24 Scopus citations


Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.

Original languageEnglish (US)
Pages (from-to)453-454
Number of pages2
JournalTrends in Endocrinology and Metabolism
Issue number9
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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