Profiling cell phenotypes and functional states using mass cytometry

Junjun Zheng; Yitian Xu; Ping Ying Pan; Shu Hsia Chen

doi:10.1016/B978-0-12-824010-6.00025-3

Profiling cell phenotypes and functional states using mass cytometry

Junjun Zheng, Yitian Xu, Ping Ying Pan, Shu Hsia Chen

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Mass cytometry technologies enable using multiple cellular biomarkers to characterize cell phenotypes and functional states at the single cell level. Cytometry by time-of-flight (CyTOF®) and Imaging Mass Cytometry™ (IMC™) have seen increasing applications in medical research from across fundamental, translational, and (pre-)clinical studies. This chapter overviews the development of mass cytometry technologies and discusses the workflows, analytical approaches as well as emerging applications.

Original language	English (US)
Title of host publication	Comprehensive Precision Medicine, First Edition, Volume 1-2
Publisher	Elsevier
Pages	V2-112-V2-120
Volume	1-2
ISBN (Electronic)	9780128240106
DOIs	https://doi.org/10.1016/B978-0-12-824010-6.00025-3
State	Published - Jan 1 2023

Keywords

Cell-cell interaction
Functional states
Immune profiling
Mass cytometry
Precision medicine
Single cell phenotyping

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-824010-6.00025-3

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keywords = "Cell-cell interaction, Functional states, Immune profiling, Mass cytometry, Precision medicine, Single cell phenotyping",

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T1 - Profiling cell phenotypes and functional states using mass cytometry

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AU - Xu, Yitian

AU - Pan, Ping Ying

AU - Chen, Shu Hsia

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Y1 - 2023/1/1

N2 - Mass cytometry technologies enable using multiple cellular biomarkers to characterize cell phenotypes and functional states at the single cell level. Cytometry by time-of-flight (CyTOF®) and Imaging Mass Cytometry™ (IMC™) have seen increasing applications in medical research from across fundamental, translational, and (pre-)clinical studies. This chapter overviews the development of mass cytometry technologies and discusses the workflows, analytical approaches as well as emerging applications.

AB - Mass cytometry technologies enable using multiple cellular biomarkers to characterize cell phenotypes and functional states at the single cell level. Cytometry by time-of-flight (CyTOF®) and Imaging Mass Cytometry™ (IMC™) have seen increasing applications in medical research from across fundamental, translational, and (pre-)clinical studies. This chapter overviews the development of mass cytometry technologies and discusses the workflows, analytical approaches as well as emerging applications.

KW - Cell-cell interaction

KW - Functional states

KW - Immune profiling

KW - Mass cytometry

KW - Precision medicine

KW - Single cell phenotyping

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M3 - Chapter

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VL - 1-2

SP - V2-112-V2-120

BT - Comprehensive Precision Medicine, First Edition, Volume 1-2

PB - Elsevier

ER -

Profiling cell phenotypes and functional states using mass cytometry

Abstract

Keywords

ASJC Scopus subject areas

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