Profile order and time-dependent artifacts in contrast-enhanced coronary MR angiography at 3T: Origin and prevention

Melanie S. Kotys, Daniel A. Herzka, Evert Jan Vonken, Jacques Ohayon, Julie Heroux, Ahmed M. Gharib, Matthias Stuber, Roderic I. Pettigrew

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


To enhance the clinical value of coronary magnetic resonance angiography (MRA), high-relaxivity contrast agents have recently been used at 3T. Here we examine a uniform bilateral shadowing artifact observed along the coronary arteries in MRA images collected using such a contrast agent. Simulations were performed to characterize this artifact, including its origin, to determine how best to mitigate this effect, and to optimize a data acquisition/injection scheme. An intraluminal contrast agent concentration model was used to simulate various acquisition strategies with two profile orders for a slow-infusion of a high-relaxivity contrast agent. Filtering effects from temporally variable weighting in k-space are prominent when a centric, radial (CR) profile order is applied during contrast infusion, resulting in decreased signal enhancement and underestimation of vessel width, while both pre- and postinfusion steadystate acquisitions result in overestimation of the vessel width. Acquisition during the brief postinfusion steady-state produces the greatest signal enhancement and minimizes k-space filtering artifacts.

Original languageEnglish (US)
Pages (from-to)292-299
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number2
StatePublished - Aug 2009


  • Contrast agent enhancement
  • Coronary artery
  • Magnetic resonance angiography artifact
  • Profile order
  • Simulation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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