Production of GABAergic cells

L RUBENSTEIN JOHN (Inventor), MARINA MIONE (Inventor), STEWART ANDERSON (Inventor), THORSTEN STUEHMER (Inventor), KYUSON YUN (Inventor)

Research output: Patent

Abstract

The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx gene (e.g., DLX1, DLX2, or DLX5) in an immature neuronal cell. The increase in Dlx activity causes differentiation of the immature neuronal cell into a neuronal cell exhibiting the GABAergic phenotype. The invention also encompasses use of GABAergic cells produced by the method of the invention in, for example, identification of agents that affect GABAergic cell activity and survival, and in replacement therapy.

Original languageEnglish (US)
Patent numberUS2002151066
IPCA61K 35/ 12 A N
Priority date7/5/01
StatePublished - Oct 17 2002

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