Probiotic-Inspired Nanomedicine Restores Intestinal Homeostasis in Colitis by Regulating Redox Balance, Immune Responses, and the Gut Microbiome

Jiaqi Xu, Junchao Xu, Tongfei Shi, Yinlong Zhang, Fangman Chen, Chao Yang, Xinjing Guo, Guangna Liu, Dan Shao, Kam W. Leong, Guangjun Nie

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the bacterial approach call for improvement. Inspired by the health benefits of probiotics in alleviating symptoms of bowel diseases, bioartificial probiotics are designed to restore the intestinal microenvironment in colitis by regulating redox balance, immune responses, and the gut microbiome. The bioartificial probiotic comprises two components: an E. coli Nissle 1917-derived membrane (EM) as the surface and the biodegradable diselenide-bridged mesoporous silica nanoparticles (SeM) as the core. When orally administered, the probiotic-inspired nanomedicine (SeM@EM) adheres strongly to the mucus layer and restored intestinal redox balance and immune regulation homeostasis in a murine model of acute colitis induced by dextran sodium sulfate. In addition, the respective properties of the EM and SeM synergistically alter the gut microbiome to a favorable state by increasing the bacterial diversity and shifting the microbiome profile to an anti-inflammatory phenotype. This work suggests a safe and effective nanomedicine that can restore intestinal homeostasis for IBDs therapy.

Original languageEnglish (US)
Article number2207890
Pages (from-to)e2207890
JournalAdvanced Materials
Issue number3
StatePublished - Jan 19 2023


  • colitis
  • diselenide-bridged mesoporous silica nanoparticles
  • EcN membrane
  • intestinal homeostasis
  • microbiota-based therapeutics
  • Dextran Sulfate/adverse effects
  • Mice, Inbred C57BL
  • Gastrointestinal Microbiome
  • Homeostasis
  • Immunity
  • Colitis/chemically induced
  • Escherichia coli/physiology
  • Animals
  • Mice
  • Nanomedicine
  • Disease Models, Animal

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Materials Science(all)


Dive into the research topics of 'Probiotic-Inspired Nanomedicine Restores Intestinal Homeostasis in Colitis by Regulating Redox Balance, Immune Responses, and the Gut Microbiome'. Together they form a unique fingerprint.

Cite this