Prinzmetal's angina during 5-fluorouracil chemotherapy

Neal Kleiman, Daniel E. Lehane, Charles E. Geyer, Craig Pratt, James B. Young

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Variant angina developed during intravenous 5-fluorouracil therapy in a patient without prior history of angina pectoris. Ambulatory electrocardiography demonstrated S-T segment elevation and ventricular ectopy during pain, whereas no symptoms or S-T segment changes occurred during placebo therapy. Prophylaxis with both nifedipine and diltiazem was successful in preventing recurrence. It is believed that 5-fluorouracil induced coronary vasospasm and that this was prevented by prophylactic calcium antagonist therapy. Drug-induced coronary artery spasm may be the cause of 5-fluorouracil-associated chest pain.

Original languageEnglish (US)
Pages (from-to)566-568
Number of pages3
JournalThe American journal of medicine
Issue number3
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Medicine(all)


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