TY - JOUR
T1 - Printing of small molecular medicines from the vapor phase
AU - Shalev, Olga
AU - Raghavan, Shreya
AU - Mazzara, J. Maxwell
AU - Senabulya, Nancy
AU - Sinko, Patrick D.
AU - Fleck, Elyse
AU - Rockwell, Christopher
AU - Simopoulos, Nicholas
AU - Jones, Christina M.
AU - Schwendeman, Anna
AU - Mehta, Geeta
AU - Clarke, Roy
AU - Amidon, Gregory E.
AU - Shtein, Max
N1 - Funding Information:
We thank Professor Adam Matzger and Dr Z. Li for discussions and UV–VIS equipment for initial experimental trials. We thank H. Erberhart for making glass nozzles. We thank Dr C.M. Schlepütz, P. Eng, J. Stubbs at sector 13-BM-C, (GeoSoilEnviroCARS), Argonne National Laboratory for their help during the XRD experiments. We thank Dr A. Lamoureux for dissolution and printing equipment component design and fabrication, as well as help with imaging of the deposits. We thank S. Paleg for assistance with surface area measurement and analysis. XRD characterization was performed thanks to resources of the Advanced Photon Source, a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under contract no. DE-AC02-06CH11357. GeoSoilEnviroCARS is supported by the National Science Foundation—Earth Sciences (EAR-0622171) and Department of Energy—Geosciences (DE-FG02-94ER14466). His work was funded in part by NSF Grant #1240264, AFOSR Grant #FA9550-12-1-0435, and the University of Michigan Grant U049584.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles. The printed films exhibit similar crystallographic order and chemistry as the original powders; controlled, order-of-magnitude enhancements of dissolution rate are observed relative to powder-form particles. In vitro treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films shows similar behavior to drugs pre-dissolved in dimethyl sulfoxide. The demonstrated precise printing of medicines as films, without the use of solvents, can accelerate drug screening and enable continuous manufacturing, while enhancing dosage accuracy.
AB - There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles. The printed films exhibit similar crystallographic order and chemistry as the original powders; controlled, order-of-magnitude enhancements of dissolution rate are observed relative to powder-form particles. In vitro treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films shows similar behavior to drugs pre-dissolved in dimethyl sulfoxide. The demonstrated precise printing of medicines as films, without the use of solvents, can accelerate drug screening and enable continuous manufacturing, while enhancing dosage accuracy.
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U2 - 10.1038/s41467-017-00763-6
DO - 10.1038/s41467-017-00763-6
M3 - Article
C2 - 28955031
AN - SCOPUS:85030121729
SN - 2041-1723
VL - 8
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 711
ER -