Primary synovial sarcoma of the kidney

Duck Hwan Kim, Jin H. Sohn, Min C. Lee, Gilho Lee, Ghil Suk Yoon, Hiroshi Hashimoto, Hiroshi Sonobe, Jae Y. Ro

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

The authors present two cases of primary synovial sarcoma of the kidney. Both patients had a mass in the upper part of the right kidney without any primary extrarenal neoplastic lesions. Grossly, the tumors were soft to rubbery masses measuring 5.5 cm and 5 cm in diameter, respectively. Histologically, both tumors were poorly differentiated synovial sarcoma. The lesions exhibited a hypercellular solid or lobular growth of round, oval, or short spindle cells in variably solid sheets, in intersecting fascicles, or in a haphazard fashion. Areas of solid aggregation or fascicles of the tumor cells alternating with hypocellular myxoid tissues, together with areas displaying a prominent hemangiopericytoma-like pattern, were found. Immunohistochemically, vimentin was diffusely positive and a few tumor cells were positive for cytokeratin, epithelial membrane antigen, and neurofilament. The tumor cells were negative for S-100 protein, CD34, smooth muscle actin, and desmin, whereas CD56 and CD99 were positive. In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX2 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma. One patient died 10 months after diagnosis. These tumors are unique cases of primary synovial sarcoma of the kidney confirmed by molecular study.

Original languageEnglish (US)
Pages (from-to)1097-1104
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume24
Issue number8
DOIs
StatePublished - Aug 2000

Keywords

  • Kidney
  • RT-PCR
  • Synovial sarcoma
  • SYT-SSX

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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