TY - JOUR
T1 - Primary rhabdomyosarcoma of the pineal gland
AU - Lau, Steven K.M.
AU - Cykowski, Matthew D.
AU - Desai, Shiv
AU - Cao, Ying
AU - Fuller, Gregory N.
AU - Bruner, Janet
AU - Okazaki, Ian
N1 - Publisher Copyright:
© American Society for Clinical Pathology.
PY - 2015/5
Y1 - 2015/5
N2 - Objectives: To report a case of primary rhabdomyosarcoma (RMS) of the pineal gland in an adult, as well as review the literature on this rare entity. Methods: The case is compared with previous reports of similar entities, with emphasis on this patient's characteristics and clinical presentation, investigations, and management. Results: Diagnosis of primary RMS of the pineal gland was based on the presence of strap cells and multinucleated myotube-like structures, as well as tumor cell expression of skeletal muscle markers consistent with myogenic differentiation. Multimodality treatment was initiated based on pediatric protocols. Unfortunately, the disease progressed on treatment, and the patient survived only 5 months from diagnosis. Conclusions: Pineal RMS is a rare disease with poor prognosis. Optimal management is unknown but likely to involve aggressive multimodality therapy.
AB - Objectives: To report a case of primary rhabdomyosarcoma (RMS) of the pineal gland in an adult, as well as review the literature on this rare entity. Methods: The case is compared with previous reports of similar entities, with emphasis on this patient's characteristics and clinical presentation, investigations, and management. Results: Diagnosis of primary RMS of the pineal gland was based on the presence of strap cells and multinucleated myotube-like structures, as well as tumor cell expression of skeletal muscle markers consistent with myogenic differentiation. Multimodality treatment was initiated based on pediatric protocols. Unfortunately, the disease progressed on treatment, and the patient survived only 5 months from diagnosis. Conclusions: Pineal RMS is a rare disease with poor prognosis. Optimal management is unknown but likely to involve aggressive multimodality therapy.
KW - Adult rhabdomyosarcoma
KW - Primary intracranial rhabdomyosarcoma
KW - Primary pineal rhabdomyosarcoma
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U2 - 10.1309/AJCP9ZON4ZIHODIG
DO - 10.1309/AJCP9ZON4ZIHODIG
M3 - Article
C2 - 25873508
AN - SCOPUS:84937130449
SN - 0002-9173
VL - 143
SP - 728
EP - 733
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 5
ER -