Primary osteosarcoma of the lung: Report of two cases and review of the literature

J. H. Loose, A. K. El-Naggar, J. Y. Ro, W. L. Huang, M. J. McMurtrey, A. G. Ayala

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Two cases of primary osteosarcoma of the lung are presented. In one case, the radiologic, clinical, and cytologic findings led to a preoperative diagnosis of undifferentiated carcinoma of the lung. In the second case, a lung nodule was discovered during postchemotherapy follow-up in a patient with lymphoma. Fine needle aspiration in the second case showed lymphoma, and further chemotherapy was instituted; however, persistent growth of the nodule prompted a resection. Microscopic examination of the resected tumors in both cases revealed histologic features of high-grade osteosarcoma. Flow cytometric analyses of the primary tumors showed abnormal hyperdiploid deoxyribonucleic acid populations in accordance with those seen in high-grade malignant neoplasms. Immunohistochemical studies supported a mesenchymal origin for these tumors. These tumors shared clinical features with other reported cases of primary osteosarcoma of the lung such as large size at diagnosis, occurrence in other individuals, and aggressive behavior.

Original languageEnglish (US)
Pages (from-to)867-873
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume100
Issue number6
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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