Primary osteosarcoma of the breast: Report of 2 cases

Armita Bahrami, Erika Resetkova, Jae Ro, Joe D. Ibañez, Alberto Ayala

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Two distinct histologic variants of primary breast osteosarcoma in 2 elderly women are described. The first patient was an 88-year-old woman with a long-standing, slow-growing, 18-cm mass in her right breast. The second patient was a 96-year-old woman with a recently self-detected, painless, 7.5-cm lump in her left breast. Clinically, there was no evidence of metastasis, and both women underwent simple mastectomy. Histologic features of both specimens were those of high-grade primary breast osteosarcoma. The first patient's tumor was classified as a chondroblastic variant, and the second as an osteoblastic variant of osteosarcoma. The patients were alive without evidence of local recurrence or hematogenous spread at a 16-and 4-month follow-up, respectively. Primary mammary osteosarcoma should be distinguished from metaplastic/ sarcomatpid carcinoma with heterologous osseous/cartilaginous differentiation or malignant phyllodes tumor because it has a different biological behavior and requires a different treatment approach.

Original languageEnglish (US)
Pages (from-to)792-795
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number5
StatePublished - May 2007

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


Dive into the research topics of 'Primary osteosarcoma of the breast: Report of 2 cases'. Together they form a unique fingerprint.

Cite this