Primary cell-mediated lympholysis response to a maternally transmitted antigen

Roger Smith Iii, David P. Huston, Robert R. Rich

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Mta-specific cytotoxic T lymphocytes (CTL) can be generated in primary cultures of (NZB x B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 x NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB or any F1 hybrid of an NZB mother. The lysis of 51Cr-labeled B10 targets is completely inhibited by unlabeled targets from Mta+ (B10.D2 x NZB)F1, but not from the reciprocal Mta-F1, thus demonstrating H-2-unrestricted lysis of Mta.

Original languageEnglish (US)
Pages (from-to)1866-1871
Number of pages6
JournalJournal of Experimental Medicine
Issue number6
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • Medicine(all)


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