Primary and secondary ataxias

Hélio A G Teive, Tetsuo Ashizawa

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


Purpose of review This article discusses recent advances in the understanding of clinical and genetic aspects of primary ataxias, including congenital, autosomal recessive, autosomal dominant, episodic, X-linked, and mitochondrial ataxias, as well as idiopathic degenerative and secondary ataxias. Recent findings Many important observations have been published in recent years in connection with primary ataxias, particularly new loci and genes. The most commonly inherited ataxias may present with typical and atypical phenotypes. In the group of idiopathic degenerative ataxias, genes have been found in patients with multiple system atrophy type C. Secondary ataxias represent an important group of sporadic, cerebellar, and afferent/sensory ataxias. Summary Knowledge of primary ataxias has been growing rapidly in recent years. Here we review different forms of primary ataxia, including inherited forms, which are subdivided into congenital, autosomal recessive cerebellar ataxias, autosomal dominant cerebellar ataxias, episodic ataxias, X-linked ataxias, and mitochondrial ataxias, as well as sporadic ataxias and idiopathic degenerative ataxias. Secondary or acquired ataxias are also reviewed and the most common causes are discussed.

Original languageEnglish (US)
Pages (from-to)413-422
Number of pages10
JournalCurrent opinion in neurology
Issue number4
StatePublished - Aug 10 2015


  • autosomal recessive cerebellar ataxias
  • congenital ataxias
  • secondary ataxias
  • spinocerebellar ataxias
  • sporadic ataxias

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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