Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer

Yian Wang; Weidong Wen; Jun Yi; Zhongqiu Zhang; Ronald A. Lubet; Ming You

doi:10.1158/1940-6207.CAPR-09-0221

Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer

Yian Wang, Weidong Wen, Jun Yi, Zhongqiu Zhang, Ronald A. Lubet, Ming You

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Abstract

In the present study, we examined the effect of bexarotene (Targretin) and budesonide in the chemoprevention of small cell lung carcinoma using a lung-specific knockout model of Rb1 and p53. Upon treatment with bexarotene, tumor incidence, number, and load were significantly reduced (P < 0.05). Budesonide treatment trended to inhibition, but the effect was not statistically significant (P > 0.05). Immunohistochemical staining indicated that bexarotene treatment decreased cell proliferation and increased apoptosis in tumors. The Rb1/ p53 gene-targeted mouse seems to be a valuable model for chemopreventive studies on human small cell lung cancer. Our results indicate that the retinoid X receptor agonist bexarotene may be a potent chemopreventive agent in this cancer type.

Original language	English (US)
Pages (from-to)	1059-1064
Number of pages	6
Journal	Cancer Prevention Research
Volume	2
Issue number	12
DOIs	https://doi.org/10.1158/1940-6207.CAPR-09-0221
State	Published - Dec 2009

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer",

abstract = "In the present study, we examined the effect of bexarotene (Targretin) and budesonide in the chemoprevention of small cell lung carcinoma using a lung-specific knockout model of Rb1 and p53. Upon treatment with bexarotene, tumor incidence, number, and load were significantly reduced (P < 0.05). Budesonide treatment trended to inhibition, but the effect was not statistically significant (P > 0.05). Immunohistochemical staining indicated that bexarotene treatment decreased cell proliferation and increased apoptosis in tumors. The Rb1/ p53 gene-targeted mouse seems to be a valuable model for chemopreventive studies on human small cell lung cancer. Our results indicate that the retinoid X receptor agonist bexarotene may be a potent chemopreventive agent in this cancer type.",

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AU - Wen, Weidong

AU - Yi, Jun

AU - Zhang, Zhongqiu

AU - Lubet, Ronald A.

AU - You, Ming

PY - 2009/12

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AB - In the present study, we examined the effect of bexarotene (Targretin) and budesonide in the chemoprevention of small cell lung carcinoma using a lung-specific knockout model of Rb1 and p53. Upon treatment with bexarotene, tumor incidence, number, and load were significantly reduced (P < 0.05). Budesonide treatment trended to inhibition, but the effect was not statistically significant (P > 0.05). Immunohistochemical staining indicated that bexarotene treatment decreased cell proliferation and increased apoptosis in tumors. The Rb1/ p53 gene-targeted mouse seems to be a valuable model for chemopreventive studies on human small cell lung cancer. Our results indicate that the retinoid X receptor agonist bexarotene may be a potent chemopreventive agent in this cancer type.

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Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer

Abstract

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