TY - JOUR
T1 - Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice
AU - Giridharan, Vijayasree V.
AU - Thandavarayan, Rajarajan A.
AU - Sato, Shinji
AU - Ko, Kam Ming
AU - Konishi, Tetsuya
N1 - Funding Information:
This study was supported by a grant to TK from the Promotion and Mutual Aid Corporation for Private Schools.The authors thank the Rotary Yoneyama Scholarship Association for the financial assistance to VVG.
PY - 2011/8
Y1 - 2011/8
N2 - The preventive effect of schisandrin B (Sch B), an antioxidant ingredient of Schisandra chinensis, was studied on scopolamine-induced dementia in mouse. Scopolamine developed oxidative stress in the brain with the decreased levels of antioxidant enzymes and increased nitrite level. At the same time, a significant impairment of learning and memory occurred when evaluated by passive avoidance task (PAT) and Morris water maze (MWM) with concomitant increase of acetylcholinesterase (AChE) activity and decreased acetylcholine levels. Pre-treatment by Sch B (10, 25, 50 mg/kg) effectively prevented scopolamine-induced oxidative stress and improved behavioural tasks. Further, the scopolamine-induced increase in AChE activity was significantly suppressed and the level of acetylcholine was maintained as normal by Sch B treatment. These results suggest that Sch B have protective function against cerebral functional defects such as dementia not only by antioxidant prevention but also exerting its potent cognitive-enhancing activity through modulation of acetylcholine level.
AB - The preventive effect of schisandrin B (Sch B), an antioxidant ingredient of Schisandra chinensis, was studied on scopolamine-induced dementia in mouse. Scopolamine developed oxidative stress in the brain with the decreased levels of antioxidant enzymes and increased nitrite level. At the same time, a significant impairment of learning and memory occurred when evaluated by passive avoidance task (PAT) and Morris water maze (MWM) with concomitant increase of acetylcholinesterase (AChE) activity and decreased acetylcholine levels. Pre-treatment by Sch B (10, 25, 50 mg/kg) effectively prevented scopolamine-induced oxidative stress and improved behavioural tasks. Further, the scopolamine-induced increase in AChE activity was significantly suppressed and the level of acetylcholine was maintained as normal by Sch B treatment. These results suggest that Sch B have protective function against cerebral functional defects such as dementia not only by antioxidant prevention but also exerting its potent cognitive-enhancing activity through modulation of acetylcholine level.
KW - Acetylcholinesterase
KW - Antioxidant
KW - Oxidative stress
KW - Schisandrin b
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UR - http://www.scopus.com/inward/citedby.url?scp=79960099131&partnerID=8YFLogxK
U2 - 10.3109/10715762.2011.571682
DO - 10.3109/10715762.2011.571682
M3 - Article
C2 - 21615274
AN - SCOPUS:79960099131
SN - 1071-5762
VL - 45
SP - 950
EP - 958
JO - Free Radical Research
JF - Free Radical Research
IS - 8
ER -