Prevalence and correlates of left ventricular hypertrophy in the african american study of kidney disease cohort study

Research output: Contribution to journalArticle

Gail E. Peterson, Tine De Backer, Avril Gabriel, Vladimir Ilic, Tudor Vagaonescu, Lawrence J. Appel, Gabriel Contreras, Cindy Kendrick, Stephen Rostand, Robert A. Phillips

African Americans with hypertensive renal disease represent a high-risk population for cardiovascular events. Although left ventricular hypertrophy is a strong predictor of adverse cardiac outcome, the prevalence and associated factors of left ventricular hypertrophy in this patient population are not well described. The African American Study of Kidney Disease Cohort Study is a prospective, observational study that is an extension of the African American Study of Kidney Disease randomized clinical trial that was conducted from 1994 to 2001 in African Americans with hypertension and mild-to-moderate renal dysfunction. Echocardiograms and 24-hour ambulatory blood pressure monitoring were performed at the baseline visit of the cohort. Of 691 patients enrolled in the cohort study, 599 patients had interpretable baseline echocardiograms and ambulatory blood pressure data. Left ventricular hypertrophy was defined using a cut point for left ventricular mass index >49.2 g/m in men and >46.7 m/m in women. The majority of patients had left ventricular hypertrophy (66.7% of men and 73.9% of women). In a multiple regression analysis, higher average day and nighttime systolic blood pressure, younger age, and lower predicted glomerular filtration rate were associated with left ventricular hypertrophy, but albuminuria was not. These data demonstrate a striking prevalence of left ventricular hypertrophy in the African American Study of Kidney Disease Cohort and identify potential targets for prevention and therapeutic intervention in this high-risk patient population.

Original languageEnglish (US)
Pages (from-to)1033-1039
Number of pages7
JournalHypertension
Volume50
Issue number6
DOIs
StatePublished - Dec 1 2007

PMID: 17968003

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Prevalence and correlates of left ventricular hypertrophy in the african american study of kidney disease cohort study. / Peterson, Gail E.; De Backer, Tine; Gabriel, Avril; Ilic, Vladimir; Vagaonescu, Tudor; Appel, Lawrence J.; Contreras, Gabriel; Kendrick, Cindy; Rostand, Stephen; Phillips, Robert A.

In: Hypertension, Vol. 50, No. 6, 01.12.2007, p. 1033-1039.

Research output: Contribution to journalArticle

Harvard

Peterson, GE, De Backer, T, Gabriel, A, Ilic, V, Vagaonescu, T, Appel, LJ, Contreras, G, Kendrick, C, Rostand, S & Phillips, RA 2007, 'Prevalence and correlates of left ventricular hypertrophy in the african american study of kidney disease cohort study' Hypertension, vol. 50, no. 6, pp. 1033-1039. https://doi.org/10.1161/HYPERTENSIONAHA.107.090613

APA

Peterson, G. E., De Backer, T., Gabriel, A., Ilic, V., Vagaonescu, T., Appel, L. J., ... Phillips, R. A. (2007). Prevalence and correlates of left ventricular hypertrophy in the african american study of kidney disease cohort study. Hypertension, 50(6), 1033-1039. https://doi.org/10.1161/HYPERTENSIONAHA.107.090613

Vancouver

Peterson GE, De Backer T, Gabriel A, Ilic V, Vagaonescu T, Appel LJ et al. Prevalence and correlates of left ventricular hypertrophy in the african american study of kidney disease cohort study. Hypertension. 2007 Dec 1;50(6):1033-1039. https://doi.org/10.1161/HYPERTENSIONAHA.107.090613

Author

Peterson, Gail E. ; De Backer, Tine ; Gabriel, Avril ; Ilic, Vladimir ; Vagaonescu, Tudor ; Appel, Lawrence J. ; Contreras, Gabriel ; Kendrick, Cindy ; Rostand, Stephen ; Phillips, Robert A. / Prevalence and correlates of left ventricular hypertrophy in the african american study of kidney disease cohort study. In: Hypertension. 2007 ; Vol. 50, No. 6. pp. 1033-1039.

BibTeX

@article{a172b931a992457a9216212054398976,
title = "Prevalence and correlates of left ventricular hypertrophy in the african american study of kidney disease cohort study",
abstract = "African Americans with hypertensive renal disease represent a high-risk population for cardiovascular events. Although left ventricular hypertrophy is a strong predictor of adverse cardiac outcome, the prevalence and associated factors of left ventricular hypertrophy in this patient population are not well described. The African American Study of Kidney Disease Cohort Study is a prospective, observational study that is an extension of the African American Study of Kidney Disease randomized clinical trial that was conducted from 1994 to 2001 in African Americans with hypertension and mild-to-moderate renal dysfunction. Echocardiograms and 24-hour ambulatory blood pressure monitoring were performed at the baseline visit of the cohort. Of 691 patients enrolled in the cohort study, 599 patients had interpretable baseline echocardiograms and ambulatory blood pressure data. Left ventricular hypertrophy was defined using a cut point for left ventricular mass index >49.2 g/m in men and >46.7 m/m in women. The majority of patients had left ventricular hypertrophy (66.7{\%} of men and 73.9{\%} of women). In a multiple regression analysis, higher average day and nighttime systolic blood pressure, younger age, and lower predicted glomerular filtration rate were associated with left ventricular hypertrophy, but albuminuria was not. These data demonstrate a striking prevalence of left ventricular hypertrophy in the African American Study of Kidney Disease Cohort and identify potential targets for prevention and therapeutic intervention in this high-risk patient population.",
keywords = "African Americans, Ambulatory, Blood pressure monitoring, Chronic, Echocardiography, Hypertension, Hypertrophy, Kidney failure, Left ventricular",
author = "Peterson, {Gail E.} and {De Backer}, Tine and Avril Gabriel and Vladimir Ilic and Tudor Vagaonescu and Appel, {Lawrence J.} and Gabriel Contreras and Cindy Kendrick and Stephen Rostand and Phillips, {Robert A.}",
year = "2007",
month = "12",
day = "1",
doi = "10.1161/HYPERTENSIONAHA.107.090613",
language = "English (US)",
volume = "50",
pages = "1033--1039",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Prevalence and correlates of left ventricular hypertrophy in the african american study of kidney disease cohort study

AU - Peterson, Gail E.

AU - De Backer, Tine

AU - Gabriel, Avril

AU - Ilic, Vladimir

AU - Vagaonescu, Tudor

AU - Appel, Lawrence J.

AU - Contreras, Gabriel

AU - Kendrick, Cindy

AU - Rostand, Stephen

AU - Phillips, Robert A.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - African Americans with hypertensive renal disease represent a high-risk population for cardiovascular events. Although left ventricular hypertrophy is a strong predictor of adverse cardiac outcome, the prevalence and associated factors of left ventricular hypertrophy in this patient population are not well described. The African American Study of Kidney Disease Cohort Study is a prospective, observational study that is an extension of the African American Study of Kidney Disease randomized clinical trial that was conducted from 1994 to 2001 in African Americans with hypertension and mild-to-moderate renal dysfunction. Echocardiograms and 24-hour ambulatory blood pressure monitoring were performed at the baseline visit of the cohort. Of 691 patients enrolled in the cohort study, 599 patients had interpretable baseline echocardiograms and ambulatory blood pressure data. Left ventricular hypertrophy was defined using a cut point for left ventricular mass index >49.2 g/m in men and >46.7 m/m in women. The majority of patients had left ventricular hypertrophy (66.7% of men and 73.9% of women). In a multiple regression analysis, higher average day and nighttime systolic blood pressure, younger age, and lower predicted glomerular filtration rate were associated with left ventricular hypertrophy, but albuminuria was not. These data demonstrate a striking prevalence of left ventricular hypertrophy in the African American Study of Kidney Disease Cohort and identify potential targets for prevention and therapeutic intervention in this high-risk patient population.

AB - African Americans with hypertensive renal disease represent a high-risk population for cardiovascular events. Although left ventricular hypertrophy is a strong predictor of adverse cardiac outcome, the prevalence and associated factors of left ventricular hypertrophy in this patient population are not well described. The African American Study of Kidney Disease Cohort Study is a prospective, observational study that is an extension of the African American Study of Kidney Disease randomized clinical trial that was conducted from 1994 to 2001 in African Americans with hypertension and mild-to-moderate renal dysfunction. Echocardiograms and 24-hour ambulatory blood pressure monitoring were performed at the baseline visit of the cohort. Of 691 patients enrolled in the cohort study, 599 patients had interpretable baseline echocardiograms and ambulatory blood pressure data. Left ventricular hypertrophy was defined using a cut point for left ventricular mass index >49.2 g/m in men and >46.7 m/m in women. The majority of patients had left ventricular hypertrophy (66.7% of men and 73.9% of women). In a multiple regression analysis, higher average day and nighttime systolic blood pressure, younger age, and lower predicted glomerular filtration rate were associated with left ventricular hypertrophy, but albuminuria was not. These data demonstrate a striking prevalence of left ventricular hypertrophy in the African American Study of Kidney Disease Cohort and identify potential targets for prevention and therapeutic intervention in this high-risk patient population.

KW - African Americans

KW - Ambulatory

KW - Blood pressure monitoring

KW - Chronic

KW - Echocardiography

KW - Hypertension

KW - Hypertrophy

KW - Kidney failure

KW - Left ventricular

UR - http://www.scopus.com/inward/record.url?scp=36448943538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36448943538&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.107.090613

DO - 10.1161/HYPERTENSIONAHA.107.090613

M3 - Article

VL - 50

SP - 1033

EP - 1039

JO - Hypertension

T2 - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 6

ER -

ID: 16799994