Presynaptic serotoninergic regulation of emotional processing: A multimodal brain imaging study

Sudhakar Selvaraj, Elias Mouchlianitis, Paul Faulkner, Federico Turkheimer, Philip J. Cowen, Jonathan P. Roiser, Oliver Howes

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background The amygdala is a central node in the brain network that processes aversive emotions and is extensively innervated by dorsal raphe nucleus (DRN) serotonin (5-hydroxytryptamine [5-HT]) neurons. Alterations in DRN 5-HT1A receptor availability cause phenotypes characterized by fearful behavior in preclinical models. However, it is unknown whether 5-HT1A receptor availability is linked specifically to the processing of aversive emotions in humans or whether it modulates connectivity in brain networks involved in emotion processing. To answer this question, we investigated the relationship between DRN 5-HT1A receptor availability and amygdala reactivity to aversive emotion and functional connectivity within the amygdala-cortical network. Methods We studied 15 healthy human participants who underwent positron emission tomography scanning with [11C]CUMI-101, a 5-HT1A partial agonist radioligand, and functional magnetic resonance imaging of brain responses during an incidental emotion processing task including happy, fearful, and neutral faces. Regional estimates of 5-HT1A receptor binding potential (nondisplaceable) were obtained by calculating total volumes of distribution for presynaptic DRN and amygdala. Connectivity between the amygdala and corticolimbic areas was assessed using psychophysiologic interaction analysis with the amygdala as the seed region. Results Analysis of the fear versus neutral contrast revealed a significant negative correlation between amygdala response and DRN binding potential (nondisplaceable) (r = -.87, p <.001). Availability of DRN 5-HT1A receptors positively correlated with amygdala connectivity with middle frontal gyrus, anterior cingulate cortex, bilateral precuneus, and left supramarginal gyrus for fearful (relative to neutral) faces. Conclusions Our data show that DRN 5-HT1A receptor availability is linked specifically to the processing of aversive emotions in the amygdala and the modulation of amygdala-cortical connectivity.

Original languageEnglish (US)
Pages (from-to)563-571
Number of pages9
JournalBiological Psychiatry
Volume78
Issue number8
DOIs
StatePublished - Oct 15 2015

Keywords

  • 5-HT receptor
  • Amygdala
  • Dorsal raphe nucleus
  • Emotion
  • Face processing
  • Functional connectivity
  • Functional magnetic resonance imaging
  • Neuroimaging
  • Positron emission tomography (PET)
  • Serotonin (5-HT)
  • [C]CUMI-101

ASJC Scopus subject areas

  • Biological Psychiatry

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