Pressure effects on enzyme structure and function in vitro and under simulated in vivo conditions

Philip Low, George N. Somero

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

1. 1. The sources and magnitudes of pressure effects on enzymic structure and function are discussed. 2. 2. Data suggest that, except for enzyme-ligand interactions, enzymes of abyssal organisms are highly similar to the homologous enzymes of shallow water and terrestrial species. 3. 3. The magnitude of pressure effects on enzymic processes is critically dependent on the experimental conditions used, including pH, ionic strength, ionic composition, ligand concentrations and temperature. The more closely in vitro conditions approach the intracellular milieu of the enzyme, the smaller is the effect of pressure on many enzymic properties.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume52
Issue number1
DOIs
StatePublished - Sep 15 1975

Keywords

  • Abyssal fishes
  • Activation volumes
  • Hydrophobic interactions
  • Hydrostatic pressure
  • Pressure adaptation
  • Protein denaturation

ASJC Scopus subject areas

  • Medicine(all)

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