Presence of the Dr receptor in normal human tissues and its possible role in the pathogenesis of ascending urinary tract infection

B. Nowicki, Luan Truong, J. Moulds, R. Hull

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The Dr hemagglutinin of uropathogenic Escherichia coli recognizes the Dra blood group antigen, a component of the IFC or Cromer-related blood group complex. The present report used the Dr hemagglutinin to demonstrate location of the Dr receptor in selected human tissues and to evaluate the possible use of this lectin as a tissue marker recognizing sites sensitive for bacterial colonization. It was found that the Dr receptor was expressed in different parts of the digestive, urinary, genital, and respiratory tracts, and skin. Intense staining by Dr hemagglutinin was shown in colonic, bronchial, and endometrial glands, and skin eccrine sweat glands. Structures of the urinary tract showing strong fluorescence were renal tubular basement membrane, Bowmans' capsule, and transitional epithelium. The role of Dra antigen as receptor for adhesion for Dr-positive E. coli in ascending colonization of urinary tract and the possible importance of Dra in human pathology is discussed.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalAmerican Journal of Pathology
Volume133
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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