Presence of glucocorticoid receptor immunoreactivity in corticotrophin releasing factor and in growth hormone releasing factor immunoreactive neurons of the rat di- and telencephalon

Antonio Cintra, Kjell Fuxe, Anders Härfstrand, Luigi F. Agnati, Ann Charlotte Wikström, Sam Okret, Wylie Vale, Jan Åke Gustafsson

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

By means of the indirect immunoperoxidase technique using two-color immunocytochemistry a moderate to strong nuclear glucocorticoid receptor (GR) immunoreactivity was demonstrated in the vast majority of the corticotrophin-releasing factor (CRF)-immunoreactive nerve cells of the parvocellular parts of the paraventricular hypothalamic nucleus, of the septohypothalamic nucleus, of the bed nucleus striae terminalis and of the central and medial amygdaloid nuclei. All the growth hormone-releasing factor (GRF)-immunoreactive nerve cells of the lateral magnocellular part of the arcuate nucleus in its entire rostrocaudal extent showed a moderate GR immunoreactivity. These results and others indicate that glucocorticoids may directly affect all the CRF and GRF cell populations projecting into the median eminence as well as CRF and GRF neurons controlling behavioral and autonomic functions.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalNeuroscience Letters
Volume77
Issue number1
DOIs
StatePublished - Jun 1 1987

Keywords

  • Corticotrophin-releasing factor (CRF)
  • Glucocorticoid receptor
  • Hypothalamus
  • Immunocytochemistry
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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