Abstract
Functionalized magnesiated aniline derivatives were readily prepared by using a bromine- or iodine-magnesium exchange. Formamidine or benzimine were found to be excellent protecting groups of the amino function for the generation of functionalized aminated Grignard reagents. These organomagnesium reagents react with various electrophiles such as aldehydes, iodoenones and allylic halides in excellent yields. After transmetallation with ZnBr2, Pd(0)-catalyzed cross-coupling with aryl iodides can be readily performed.
Original language | English (US) |
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Pages (from-to) | 477-480 |
Number of pages | 4 |
Journal | Synlett |
Issue number | 4 |
DOIs | |
State | Published - 2001 |
Keywords
- Bromine-magnesium exchange
- Cross-coupling reactions
- Heterocycles
- Magnesium
ASJC Scopus subject areas
- Organic Chemistry