Preparation, characterization, and cellular associations of silicon logic-embedded vectors

Anne L Van De Ven; Aaron MacK; Kenneth Dunner; Mauro Ferrari; Rita Serda

doi:10.1016/B978-0-12-391860-4.00001-X

Preparation, characterization, and cellular associations of silicon logic-embedded vectors

Anne L Van De Ven, Aaron MacK, Kenneth Dunner, Mauro Ferrari, Rita Serda

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Logic-embedded vectors (LEVs) have been introduced as a means to overcome sequential, biological barriers that prevent particle-based drug delivery systems from reaching their targets. In this chapter, we address the challenge of fabricating and optimizing LEVs to reach non-endosomal targets. We describe the general preparation, characterization, and cellular association of porous silicon-based LEVs. A specific example of LEV fabrication from start to finish, along with optimization and troubleshooting information, is presented to serve as a template for future designs.

Original language	English
Pages (from-to)	1-16
Number of pages	16
Journal	Methods in Enzymology
Volume	508
DOIs	https://doi.org/10.1016/B978-0-12-391860-4.00001-X
State	Published - Apr 2 2012

Keywords

Chitosan
Intracellular trafficking
Iron oxide
Microparticles
Multistage
Nanoparticles
Porous silicon

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/B978-0-12-391860-4.00001-X

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title = "Preparation, characterization, and cellular associations of silicon logic-embedded vectors",

abstract = "Logic-embedded vectors (LEVs) have been introduced as a means to overcome sequential, biological barriers that prevent particle-based drug delivery systems from reaching their targets. In this chapter, we address the challenge of fabricating and optimizing LEVs to reach non-endosomal targets. We describe the general preparation, characterization, and cellular association of porous silicon-based LEVs. A specific example of LEV fabrication from start to finish, along with optimization and troubleshooting information, is presented to serve as a template for future designs.",

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AU - De Ven, Anne L Van

AU - MacK, Aaron

AU - Dunner, Kenneth

AU - Ferrari, Mauro

AU - Serda, Rita

PY - 2012/4/2

Y1 - 2012/4/2

N2 - Logic-embedded vectors (LEVs) have been introduced as a means to overcome sequential, biological barriers that prevent particle-based drug delivery systems from reaching their targets. In this chapter, we address the challenge of fabricating and optimizing LEVs to reach non-endosomal targets. We describe the general preparation, characterization, and cellular association of porous silicon-based LEVs. A specific example of LEV fabrication from start to finish, along with optimization and troubleshooting information, is presented to serve as a template for future designs.

AB - Logic-embedded vectors (LEVs) have been introduced as a means to overcome sequential, biological barriers that prevent particle-based drug delivery systems from reaching their targets. In this chapter, we address the challenge of fabricating and optimizing LEVs to reach non-endosomal targets. We describe the general preparation, characterization, and cellular association of porous silicon-based LEVs. A specific example of LEV fabrication from start to finish, along with optimization and troubleshooting information, is presented to serve as a template for future designs.

KW - Chitosan

KW - Intracellular trafficking

KW - Iron oxide

KW - Microparticles

KW - Multistage

KW - Nanoparticles

KW - Porous silicon

UR - https://www.scopus.com/pages/publications/84859091718

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U2 - 10.1016/B978-0-12-391860-4.00001-X

DO - 10.1016/B978-0-12-391860-4.00001-X

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AN - SCOPUS:84859091718

SN - 0076-6879

VL - 508

SP - 1

EP - 16

JO - Methods in Enzymology

JF - Methods in Enzymology

ER -

Preparation, characterization, and cellular associations of silicon logic-embedded vectors

Abstract

Keywords

ASJC Scopus subject areas

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