Preparation, characterization, and cellular associations of silicon logic-embedded vectors

Anne L Van De Ven, Aaron MacK, Kenneth Dunner, Mauro Ferrari, Rita Serda

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Logic-embedded vectors (LEVs) have been introduced as a means to overcome sequential, biological barriers that prevent particle-based drug delivery systems from reaching their targets. In this chapter, we address the challenge of fabricating and optimizing LEVs to reach non-endosomal targets. We describe the general preparation, characterization, and cellular association of porous silicon-based LEVs. A specific example of LEV fabrication from start to finish, along with optimization and troubleshooting information, is presented to serve as a template for future designs.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalMethods in Enzymology
Volume508
DOIs
StatePublished - Apr 2 2012

Keywords

  • Chitosan
  • Intracellular trafficking
  • Iron oxide
  • Microparticles
  • Multistage
  • Nanoparticles
  • Porous silicon

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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