Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone)

P. Prabu, N. Dharmaraj, Santosh Aryal, B. M. Lee, Vijaya Ramesh, H. Y. Kim

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

A new biodegradable polymeric scaffold was prepared by using collagen and poly(caprolatctone) (PCL). These scaffolds were found to be soft, spongy, and transparent in nature and characterized by thermogravimetric analysis and FTIR spectrum. To these biodegradable polymeric scaffolds, antibiotic drugs namely amikacin and gentamycin were incorporated separately to study their release pattern from scaffolds. Amikacin and gentamycin release activity of the scaffolds containing a constant quantity of collagen but different quantities of PCL were studied at various time intervals viz. 1, 4, 24, and 48 h by measuring the optical density at 257 and 255 nm, respectively.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Volume79
Issue number1
DOIs
StatePublished - Oct 1 2006

Keywords

  • Amikacin
  • Collagen
  • Gentamycin
  • Poly(caprolactone)
  • Scaffolds

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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