Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone)

P. Prabu; N. Dharmaraj; Santosh Aryal; B. M. Lee; Vijaya Ramesh; H. Y. Kim

doi:10.1002/jbm.a.30715

Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone)

P. Prabu, N. Dharmaraj, Santosh Aryal, B. M. Lee, Vijaya Ramesh, H. Y. Kim

Houston Methodist

Research output: Contribution to journal › Article

42 Scopus citations

Abstract

A new biodegradable polymeric scaffold was prepared by using collagen and poly(caprolatctone) (PCL). These scaffolds were found to be soft, spongy, and transparent in nature and characterized by thermogravimetric analysis and FTIR spectrum. To these biodegradable polymeric scaffolds, antibiotic drugs namely amikacin and gentamycin were incorporated separately to study their release pattern from scaffolds. Amikacin and gentamycin release activity of the scaffolds containing a constant quantity of collagen but different quantities of PCL were studied at various time intervals viz. 1, 4, 24, and 48 h by measuring the optical density at 257 and 255 nm, respectively.

Original language	English (US)
Pages (from-to)	153-158
Number of pages	6
Journal	Journal of Biomedical Materials Research - Part A
Volume	79
Issue number	1
DOIs	https://doi.org/10.1002/jbm.a.30715
State	Published - Oct 1 2006

Keywords

Amikacin
Collagen
Gentamycin
Poly(caprolactone)
Scaffolds

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials

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