Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone)

P. Prabu; N. Dharmaraj; Santosh Aryal; B. M. Lee; Vijaya Ramesh; H. Y. Kim

doi:10.1002/jbm.a.30715

Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone)

P. Prabu, N. Dharmaraj, Santosh Aryal, B. M. Lee, Vijaya Ramesh, H. Y. Kim

Houston Methodist

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

A new biodegradable polymeric scaffold was prepared by using collagen and poly(caprolatctone) (PCL). These scaffolds were found to be soft, spongy, and transparent in nature and characterized by thermogravimetric analysis and FTIR spectrum. To these biodegradable polymeric scaffolds, antibiotic drugs namely amikacin and gentamycin were incorporated separately to study their release pattern from scaffolds. Amikacin and gentamycin release activity of the scaffolds containing a constant quantity of collagen but different quantities of PCL were studied at various time intervals viz. 1, 4, 24, and 48 h by measuring the optical density at 257 and 255 nm, respectively.

Original language	English (US)
Pages (from-to)	153-158
Number of pages	6
Journal	Journal of Biomedical Materials Research - Part A
Volume	79
Issue number	1
DOIs	https://doi.org/10.1002/jbm.a.30715
State	Published - Oct 2006

Keywords

Amikacin
Collagen
Gentamycin
Poly(caprolactone)
Scaffolds

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials

Access to Document

10.1002/jbm.a.30715

Cite this

@article{402d8c6134f941a583de080f36abbf72,

title = "Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone)",

abstract = "A new biodegradable polymeric scaffold was prepared by using collagen and poly(caprolatctone) (PCL). These scaffolds were found to be soft, spongy, and transparent in nature and characterized by thermogravimetric analysis and FTIR spectrum. To these biodegradable polymeric scaffolds, antibiotic drugs namely amikacin and gentamycin were incorporated separately to study their release pattern from scaffolds. Amikacin and gentamycin release activity of the scaffolds containing a constant quantity of collagen but different quantities of PCL were studied at various time intervals viz. 1, 4, 24, and 48 h by measuring the optical density at 257 and 255 nm, respectively.",

keywords = "Amikacin, Collagen, Gentamycin, Poly(caprolactone), Scaffolds",

author = "P. Prabu and N. Dharmaraj and Santosh Aryal and Lee, {B. M.} and Vijaya Ramesh and Kim, {H. Y.}",

year = "2006",

month = oct,

doi = "10.1002/jbm.a.30715",

language = "English (US)",

volume = "79",

pages = "153--158",

journal = "Journal of Biomedical Materials Research - Part A",

issn = "0021-9304",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone)

AU - Prabu, P.

AU - Dharmaraj, N.

AU - Aryal, Santosh

AU - Lee, B. M.

AU - Ramesh, Vijaya

AU - Kim, H. Y.

PY - 2006/10

Y1 - 2006/10

N2 - A new biodegradable polymeric scaffold was prepared by using collagen and poly(caprolatctone) (PCL). These scaffolds were found to be soft, spongy, and transparent in nature and characterized by thermogravimetric analysis and FTIR spectrum. To these biodegradable polymeric scaffolds, antibiotic drugs namely amikacin and gentamycin were incorporated separately to study their release pattern from scaffolds. Amikacin and gentamycin release activity of the scaffolds containing a constant quantity of collagen but different quantities of PCL were studied at various time intervals viz. 1, 4, 24, and 48 h by measuring the optical density at 257 and 255 nm, respectively.

AB - A new biodegradable polymeric scaffold was prepared by using collagen and poly(caprolatctone) (PCL). These scaffolds were found to be soft, spongy, and transparent in nature and characterized by thermogravimetric analysis and FTIR spectrum. To these biodegradable polymeric scaffolds, antibiotic drugs namely amikacin and gentamycin were incorporated separately to study their release pattern from scaffolds. Amikacin and gentamycin release activity of the scaffolds containing a constant quantity of collagen but different quantities of PCL were studied at various time intervals viz. 1, 4, 24, and 48 h by measuring the optical density at 257 and 255 nm, respectively.

KW - Amikacin

KW - Collagen

KW - Gentamycin

KW - Poly(caprolactone)

KW - Scaffolds

UR - http://www.scopus.com/inward/record.url?scp=33749039465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749039465&partnerID=8YFLogxK

U2 - 10.1002/jbm.a.30715

DO - 10.1002/jbm.a.30715

M3 - Article

C2 - 16779770

AN - SCOPUS:33749039465

SN - 0021-9304

VL - 79

SP - 153

EP - 158

JO - Journal of Biomedical Materials Research - Part A

JF - Journal of Biomedical Materials Research - Part A

IS - 1

ER -

Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this