Preoperative risk stratification by adenosine thallium 201 single-photon emission computed tomography in patients undergoing vascular surgery

Maria G. Koutelou, P. John Asimacopoulos, John J. Mahmarian, Kay T. Kimball, Mario S. Verani

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: Adenosine perfusion scintigraphy is a powerful technique for diagnosing coronary artery disease and risk stratifying patients with recent myocardial infarction. Methods and Results: We investigated the use of adenosine 201Tl tomography to risk stratify 106 patients undergoing vascular arterial reconstruction consisting of lower limb arterial grafting in 44, aortic aneurysmectomy in 36, and carotid endarterectomy in 26 patients. Abnormal tomograms occurred in 57 patients (54%), 47 (82%) of whom had reversible perfusion defects. There were three postoperative deaths, all in the group that underwent aortic aneurysmectomy. Another patient with an aortic aneurysm had unstable angina and one patient who underwent lower limb arterial surgery had pulmonary edema after surgery. No patient without transient defects had an event (negative predictive value 100%). Cardiac events occurred only in patients with transient perfusion defects. However, only 5 of 47 such patients had events (positive predictive value 11%). The perfusion defect size (23%±14% vs 8.9%±135; p=0.034) and the ischemic fraction (20%±16% vs 5.6%±8.9%; p=0.009) were 2.5- and 3.5-fold larger, respectively, in patients with than in those without events. A history of diabetes mellius or previous infarction did not enhance the predictive value of the test. Conclusion: Thus absence of reversible hypoperfusion during adenosine scintigraphy ensures virtual absence of postoperative cardiac events. Patients undergoing aortic aneurysmectomy may be targeted preferentially for risk-stratification strategies in the future.

Original languageEnglish (US)
Pages (from-to)389-394
Number of pages6
JournalJournal of Nuclear Cardiology
Volume2
Issue number5
DOIs
StatePublished - Sep 1995

Keywords

  • adenosine thallium scintigraphy
  • preoperative risk stratification
  • vascular surgery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Preoperative risk stratification by adenosine thallium 201 single-photon emission computed tomography in patients undergoing vascular surgery'. Together they form a unique fingerprint.

Cite this