TY - JOUR
T1 - Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer
AU - Milam, Michael R.
AU - Frumovitz, Michael
AU - dos Reis, Ricardo
AU - Broaddus, Russell R.
AU - Bassett, Roland L.
AU - Ramirez, Pedro T.
PY - 2007/7
Y1 - 2007/7
N2 - Objective: To determine the association between findings on review of preoperative biopsy specimens and the risk of lymph node involvement (LNI) at radical hysterectomy in patients with early-stage cervical cancer. Methods: Eighty-one patients were included in this retrospective review. Preoperative biopsy features evaluated were stage, grade, histologic subtype, lymph-vascular space invasion (LVSI), and depth (> 4 mm) of invasion. Results: Twelve patients (14.8%) had LNI at radical hysterectomy. Stage, grade, and histologic subtype were not associated with LNI. LVSI and depth of invasion > 4 mm were both significantly associated with LNI (25.6% vs. 4.8%, P = 0.01, and 25.0% vs. 4.5%, P = 0.01, respectively). LVSI with > 4 mm invasion was 6.6 times more likely to have LNI at the time of radical hysterectomy (RR = 6.6; 95% confidence interval, 2.1-21.9). Conclusion: Patients with preoperative LVSI are at higher risk for LNI at radical hysterectomy and should be counseled regarding potential implications for management.
AB - Objective: To determine the association between findings on review of preoperative biopsy specimens and the risk of lymph node involvement (LNI) at radical hysterectomy in patients with early-stage cervical cancer. Methods: Eighty-one patients were included in this retrospective review. Preoperative biopsy features evaluated were stage, grade, histologic subtype, lymph-vascular space invasion (LVSI), and depth (> 4 mm) of invasion. Results: Twelve patients (14.8%) had LNI at radical hysterectomy. Stage, grade, and histologic subtype were not associated with LNI. LVSI and depth of invasion > 4 mm were both significantly associated with LNI (25.6% vs. 4.8%, P = 0.01, and 25.0% vs. 4.5%, P = 0.01, respectively). LVSI with > 4 mm invasion was 6.6 times more likely to have LNI at the time of radical hysterectomy (RR = 6.6; 95% confidence interval, 2.1-21.9). Conclusion: Patients with preoperative LVSI are at higher risk for LNI at radical hysterectomy and should be counseled regarding potential implications for management.
KW - Cervical cancer
KW - Lymph-vascular space invasion
KW - Radical hysterectomy
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U2 - 10.1016/j.ygyno.2007.04.010
DO - 10.1016/j.ygyno.2007.04.010
M3 - Article
C2 - 17498783
AN - SCOPUS:34250161625
SN - 0090-8258
VL - 106
SP - 12
EP - 15
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -