Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer

Michael R. Milam, Michael Frumovitz, Ricardo dos Reis, Russell R. Broaddus, Roland L. Bassett, Pedro T. Ramirez

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Objective: To determine the association between findings on review of preoperative biopsy specimens and the risk of lymph node involvement (LNI) at radical hysterectomy in patients with early-stage cervical cancer. Methods: Eighty-one patients were included in this retrospective review. Preoperative biopsy features evaluated were stage, grade, histologic subtype, lymph-vascular space invasion (LVSI), and depth (> 4 mm) of invasion. Results: Twelve patients (14.8%) had LNI at radical hysterectomy. Stage, grade, and histologic subtype were not associated with LNI. LVSI and depth of invasion > 4 mm were both significantly associated with LNI (25.6% vs. 4.8%, P = 0.01, and 25.0% vs. 4.5%, P = 0.01, respectively). LVSI with > 4 mm invasion was 6.6 times more likely to have LNI at the time of radical hysterectomy (RR = 6.6; 95% confidence interval, 2.1-21.9). Conclusion: Patients with preoperative LVSI are at higher risk for LNI at radical hysterectomy and should be counseled regarding potential implications for management.

Original languageEnglish (US)
Pages (from-to)12-15
Number of pages4
JournalGynecologic oncology
Volume106
Issue number1
DOIs
StatePublished - Jul 2007

Keywords

  • Cervical cancer
  • Lymph-vascular space invasion
  • Radical hysterectomy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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