Preoperative chemotherapy for wilms tumor

R. Bruce Bracken; Wataru W. Sutow; Norman Jaffe; Alberto Ayala; Luis Guarda

doi:10.1016/0090-4295(82)90047-4

Preoperative chemotherapy for wilms tumor

R. Bruce Bracken, Wataru W. Sutow, Norman Jaffe, Alberto Ayala, Luis Guarda

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Abstract

Preoperative chemotherapy was administered to 19 children with '17011 t c n u n judged clinically to be unresectable at M. D. Anderson Hospital between Janwar 1, 1962, and September 1, 1980. After 2 to 4 doses of vincristine, marked reduction in tumor sized occurred in 16 patients. After chemotherapy 16 tumors could be resected completely, another required irradiation to reduce the tumor, and only 2 tumors could not be excised. Pathologically the most dramatic changes occurred in the undifferentiated interstitial stroma, followed next by changes in the nodular blastema. Differentiated elements were apparently not affected. No serious complications were attributed to the preoperative drug treatment. This experience suggests that in selected instances preoperative chemotherapy can effectively facilitate the therapy of Wilms tumor.

Original language	English (US)
Pages (from-to)	55-60
Number of pages	6
Journal	Urology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/0090-4295(82)90047-4
State	Published - Jan 1 1982

ASJC Scopus subject areas

Urology

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title = "Preoperative chemotherapy for wilms tumor",

abstract = "Preoperative chemotherapy was administered to 19 children with '17011 t c n u n judged clinically to be unresectable at M. D. Anderson Hospital between Janwar 1, 1962, and September 1, 1980. After 2 to 4 doses of vincristine, marked reduction in tumor sized occurred in 16 patients. After chemotherapy 16 tumors could be resected completely, another required irradiation to reduce the tumor, and only 2 tumors could not be excised. Pathologically the most dramatic changes occurred in the undifferentiated interstitial stroma, followed next by changes in the nodular blastema. Differentiated elements were apparently not affected. No serious complications were attributed to the preoperative drug treatment. This experience suggests that in selected instances preoperative chemotherapy can effectively facilitate the therapy of Wilms tumor.",

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AU - Bruce Bracken, R.

AU - Sutow, Wataru W.

AU - Jaffe, Norman

AU - Ayala, Alberto

AU - Guarda, Luis

PY - 1982/1/1

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AB - Preoperative chemotherapy was administered to 19 children with '17011 t c n u n judged clinically to be unresectable at M. D. Anderson Hospital between Janwar 1, 1962, and September 1, 1980. After 2 to 4 doses of vincristine, marked reduction in tumor sized occurred in 16 patients. After chemotherapy 16 tumors could be resected completely, another required irradiation to reduce the tumor, and only 2 tumors could not be excised. Pathologically the most dramatic changes occurred in the undifferentiated interstitial stroma, followed next by changes in the nodular blastema. Differentiated elements were apparently not affected. No serious complications were attributed to the preoperative drug treatment. This experience suggests that in selected instances preoperative chemotherapy can effectively facilitate the therapy of Wilms tumor.

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Preoperative chemotherapy for wilms tumor

Abstract

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