Preoperative chemotherapy for osteosarcoma with intravenous adriamycin and intra-arterial cis-platinum

R. S. Benjamin, S. P. Chawla, C. H. Carrasco, A. K. Raymond, J. A. Murray, T. Armen, S. Patel, S. Wallace, A. Ayala, N. E.J. Papadopoulos, C. Plager, M. M. Romsdahl, R. G. Martin

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29 Scopus citations


Ninety-seven patients with primary osteosarcoma of the extremities, all age 16 or older, were treated with adriamycin, 90 mg/m2, continuous i.v. infusion over 96 h, followed by cis-platinum, 120-160 mg/m2 by intra-arterial infusion. The first 37 patients, treated from 1979-1982, had a 59% complete response rate and a 54% 5-year continuous disease free survival (CDFS). Patients with complete response had an 85% 5-year CDFS compared with 13% for patients with partial and poor response. Patients treated between 1983-1988 with an intensified regimen have a 68% complete response rate and a 69% 3-year CDFS. Those who did not achieve complete remission were switched to an alternating chemotherapy program emphasizing the use of high-dose methotrexate. Limb salvage has been accomplished in 59% of patients in the first group and 80% in patients of the second group. Preoperative chemotherapy allows informed decisions to be made in postoperative management which can influence overall cure rates. Long-term follow-up is essential before final interpretation of the data.

Original languageEnglish (US)
Pages (from-to)3-6
Number of pages4
JournalAnnals of Oncology
Issue numberSUPPL. 2
StatePublished - 1992

ASJC Scopus subject areas

  • Hematology
  • Oncology


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