@article{a5ef3bcd4865400d914d232895e5f1a4,
title = "Premeditated aggression is associated with serum cholesterol in abstinent drug and alcohol dependent men",
abstract = "Relationships between aggressive subtypes and lipids were explored in 18 adult males undergoing treatment for substance dependence. A positive association was observed between a measure of premeditated aggression and total cholesterol. This was in contrast to an inverse association between lower cholesterol and higher impulsivity and anxiety.",
keywords = "Aggression, Anxiety, Barratt Impulsivity Scale, Impulsive aggression, Lipids",
author = "Conklin, \{Sarah M.\} and Stanford, \{Matthew S.\}",
note = "Funding Information: Previously, associations between low serum cholesterol and negative affect, impulsivity and antisocial personality have been reported ( Pozzi et al., 2003; Vevera et al., 2003; Papakostas et al., 2004; Monteleone et al., 2005 ). The Cholesterol–Serotonin Hypothesis put forth by Engelberg et al. (1992) proposed that cholesterol, as an integral component of neural membranes, influences both membrane structure and function, particularly that of the serotonergic (5HT) receptors. This notion was supported by a series of studies manipulating the cholesterol content of laboratory chow. Of interest here, agonistic behaviors increased with cholesterol decrease ( Kaplan et al., 1991, 1994, 1996, 1997 ). Some in vitro experiments support this hypothesis. When cholesterol is experimentally removed from neural membranes, a concentration-dependent decrease occurs in agonist binding to 5HT receptors ( Pucadyil and Chattaopadhyay, 2004 ). ",
year = "2008",
month = jan,
day = "15",
doi = "10.1016/j.psychres.2007.02.006",
language = "English (US)",
volume = "157",
pages = "283--287",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "1-3",
}