Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown

Agnieszka Lechowska, Szczepan Bilinski, Youngsok Choi, Yonghyun Shin, Malgorzata Kloc, Aleksandar Rajkovic

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Purpose: To understand the mechanism of premature ovarian failure (POF). Methods: The ultrastructural (electron microscopy) analysis of primordial ovarian follicles in Nobox deficient mice. Results: We studied, for the first time, the fate of oogonia in embryonic (prenatal) mouse ovaries and showed that the abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles. Conclusions: These results indicate that POF syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development. In addition, the extremely unusual and abnormal presence of adherens junctions between unseparated oocytes within syncytial follicles indicates that faulty communication between somatic and germ cells is involved in, or leads to, abnormalities in the cell adhesion program.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume28
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • Germ cells
  • Homeobox
  • Nobox
  • Ovary
  • Premature ovarian failure

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

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