Preliminary Observations of the Effects on Breast Adenocarcinoma of Plasma Perfused over Immobilized Protein A

David S. Terman; James B. Young; William T. Shearer; Carlos Ayus; Daniel Lehane; Carlos Mattioli; Rafael Espada; Jimmy F. Howell; Tsuyoshi Yamamoto; Henry I. Zaleski; Lisa Miller; Peter Frommer; Louis Feldman; Joseph F. Henry; Richard Tillquist; Gary Cook; Yerach Daskal

doi:10.1056/NEJM198111123052006

Preliminary Observations of the Effects on Breast Adenocarcinoma of Plasma Perfused over Immobilized Protein A

David S. Terman, James B. Young, William T. Shearer, Carlos Ayus, Daniel Lehane, Carlos Mattioli, Rafael Espada, Jimmy F. Howell, Tsuyoshi Yamamoto, Henry I. Zaleski, Lisa Miller, Peter Frommer, Louis Feldman, Joseph F. Henry, Richard Tillquist, Gary Cook, Yerach Daskal

Department of Medicine

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Five consecutive patients with breast adenocarcinoma who had relapses while undergoing conventional therapy were given autologous plasma or plasma from similar patients, which had been perfused over PACC; this was sometimes followed by intravenous cytarabine, 2 to 20 mg per kilogram of body weight. After repetition of such procedures, objective partial remission or improvement was observed in four cases. These early results are preliminary, but they warrant further investigation of the mechanism involved in the antitumor effect as well as the potential therapeutic value of this technique.

Original language	English (US)
Pages (from-to)	1195-1200
Number of pages	6
Journal	New England Journal of Medicine
Volume	305
Issue number	20
DOIs	https://doi.org/10.1056/NEJM198111123052006
State	Published - Nov 12 1981

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJM198111123052006

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Terman, D. S., Young, J. B., Shearer, W. T., Ayus, C., Lehane, D., Mattioli, C., Espada, R., Howell, J. F., Yamamoto, T., Zaleski, H. I., Miller, L., Frommer, P., Feldman, L., Henry, J. F., Tillquist, R., Cook, G., & Daskal, Y. (1981). Preliminary Observations of the Effects on Breast Adenocarcinoma of Plasma Perfused over Immobilized Protein A. New England Journal of Medicine, 305(20), 1195-1200. https://doi.org/10.1056/NEJM198111123052006

Terman, DS, Young, JB, Shearer, WT, Ayus, C, Lehane, D, Mattioli, C, Espada, R, Howell, JF, Yamamoto, T, Zaleski, HI, Miller, L, Frommer, P, Feldman, L, Henry, JF, Tillquist, R, Cook, G & Daskal, Y 1981, 'Preliminary Observations of the Effects on Breast Adenocarcinoma of Plasma Perfused over Immobilized Protein A', New England Journal of Medicine, vol. 305, no. 20, pp. 1195-1200. https://doi.org/10.1056/NEJM198111123052006

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title = "Preliminary Observations of the Effects on Breast Adenocarcinoma of Plasma Perfused over Immobilized Protein A",

abstract = "Five consecutive patients with breast adenocarcinoma who had relapses while undergoing conventional therapy were given autologous plasma or plasma from similar patients, which had been perfused over PACC; this was sometimes followed by intravenous cytarabine, 2 to 20 mg per kilogram of body weight. After repetition of such procedures, objective partial remission or improvement was observed in four cases. These early results are preliminary, but they warrant further investigation of the mechanism involved in the antitumor effect as well as the potential therapeutic value of this technique.",

author = "Terman, {David S.} and Young, {James B.} and Shearer, {William T.} and Carlos Ayus and Daniel Lehane and Carlos Mattioli and Rafael Espada and Howell, {Jimmy F.} and Tsuyoshi Yamamoto and Zaleski, {Henry I.} and Lisa Miller and Peter Frommer and Louis Feldman and Henry, {Joseph F.} and Richard Tillquist and Gary Cook and Yerach Daskal",

year = "1981",

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doi = "10.1056/NEJM198111123052006",

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AU - Terman, David S.

AU - Young, James B.

AU - Shearer, William T.

AU - Ayus, Carlos

AU - Lehane, Daniel

AU - Mattioli, Carlos

AU - Espada, Rafael

AU - Howell, Jimmy F.

AU - Yamamoto, Tsuyoshi

AU - Zaleski, Henry I.

AU - Miller, Lisa

AU - Frommer, Peter

AU - Feldman, Louis

AU - Henry, Joseph F.

AU - Tillquist, Richard

AU - Cook, Gary

AU - Daskal, Yerach

PY - 1981/11/12

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AB - Five consecutive patients with breast adenocarcinoma who had relapses while undergoing conventional therapy were given autologous plasma or plasma from similar patients, which had been perfused over PACC; this was sometimes followed by intravenous cytarabine, 2 to 20 mg per kilogram of body weight. After repetition of such procedures, objective partial remission or improvement was observed in four cases. These early results are preliminary, but they warrant further investigation of the mechanism involved in the antitumor effect as well as the potential therapeutic value of this technique.

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Preliminary Observations of the Effects on Breast Adenocarcinoma of Plasma Perfused over Immobilized Protein A

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