TY - JOUR
T1 - Pregabalin for the treatment of postoperative pain
T2 - Results from three controlled trials using different surgical models
AU - Singla, Neil K.
AU - Echelly, Jacques
AU - Lionberger, David R.
AU - Gimbel, Joseph
AU - Sanin, Luis
AU - Sporn, Jonathan
AU - Yang, Ruoyong
AU - Cheung, Raymond
AU - Knapp, Lloyd
AU - Parsons, Bruce
N1 - Publisher Copyright:
© 2015 Singla et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License.
PY - 2014/12/23
Y1 - 2014/12/23
N2 - Conclusion: There were no significant differences between pregabalin and placebo with respect to the primary pain intensity measure in each of the three clinical trials. These studies encompass a large dataset (1,233 patients in total), and their results should be considered when assessing pregabalin’s effectiveness in postoperative pain. Further studies are required to determine the potential pain-reducing benefit of pregabalin in the postoperative setting.Patients and methods: This study reports findings from three separate, multicenter, randomized, double-blind, placebo-controlled trials of adjunctive pregabalin for the treatment of postoperative pain. Patients underwent one of three categories of surgical procedures (one procedure per study): elective inguinal hernia repair (post-IHR); elective total knee arthroplasty (post-TKA); or total abdominal hysterectomy (posthysterectomy). The primary endpoint in each trial, mean worst pain over the past 24 hours, was assessed 24 hours post-IHR and posthysterectomy, and 48 hours post-TKA. Patients rated their pain on a scale from 0 to 10, with higher scores indicating greater pain severity.Purpose: To evaluate the efficacy and safety of pregabalin (150 or 300 mg/d) as an adjunctive therapy for the treatment of postoperative pain.Results: In total, 425 (post-IHR), 307 (post-TKA), and 501 (posthysterectomy) patients were randomized to treatment. There were no statistically significant differences between the pregabalin and placebo groups with respect to the primary endpoint in any of the three trials. The least squares mean difference in worst pain, between 300 mg/d pregabalin and placebo, was-0.7 (95% confidence interval [CI] =-1.4,-0.1; Hochberg adjusted P=0.067) post-IHR;-0.34 (95% CI =-1.07, 0.39; P=0.362) post-TKA; and-0.2 (95% CI =-0.66, 0.31; P=0.471) posthysterectomy.
AB - Conclusion: There were no significant differences between pregabalin and placebo with respect to the primary pain intensity measure in each of the three clinical trials. These studies encompass a large dataset (1,233 patients in total), and their results should be considered when assessing pregabalin’s effectiveness in postoperative pain. Further studies are required to determine the potential pain-reducing benefit of pregabalin in the postoperative setting.Patients and methods: This study reports findings from three separate, multicenter, randomized, double-blind, placebo-controlled trials of adjunctive pregabalin for the treatment of postoperative pain. Patients underwent one of three categories of surgical procedures (one procedure per study): elective inguinal hernia repair (post-IHR); elective total knee arthroplasty (post-TKA); or total abdominal hysterectomy (posthysterectomy). The primary endpoint in each trial, mean worst pain over the past 24 hours, was assessed 24 hours post-IHR and posthysterectomy, and 48 hours post-TKA. Patients rated their pain on a scale from 0 to 10, with higher scores indicating greater pain severity.Purpose: To evaluate the efficacy and safety of pregabalin (150 or 300 mg/d) as an adjunctive therapy for the treatment of postoperative pain.Results: In total, 425 (post-IHR), 307 (post-TKA), and 501 (posthysterectomy) patients were randomized to treatment. There were no statistically significant differences between the pregabalin and placebo groups with respect to the primary endpoint in any of the three trials. The least squares mean difference in worst pain, between 300 mg/d pregabalin and placebo, was-0.7 (95% confidence interval [CI] =-1.4,-0.1; Hochberg adjusted P=0.067) post-IHR;-0.34 (95% CI =-1.07, 0.39; P=0.362) post-TKA; and-0.2 (95% CI =-0.66, 0.31; P=0.471) posthysterectomy.
KW - Arthroplasty
KW - Herniorrhaphy
KW - Hysterectomy
KW - Postoperative pain
KW - Pregabalin
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U2 - 10.2147/JPR.S67841
DO - 10.2147/JPR.S67841
M3 - Article
AN - SCOPUS:84919788837
SN - 1178-7090
VL - 8
SP - 9
EP - 20
JO - Journal of Pain Research
JF - Journal of Pain Research
ER -