TY - JOUR
T1 - Predictors of persistent central serous chorioretinopathy
T2 - a multicenter retrospective study – MICRoN report number four
AU - for the Macula Society International CSCR Research Network – MICRoN, MICRoN study group
AU - Gandhi, Priyanka
AU - Hasan, Nasiq
AU - Gidwani, Korrina
AU - Yang, Jonathan
AU - Cao, Jessica
AU - Saju, Stanley
AU - Wykoff, Charles C.
AU - Khateb, Samer
AU - Kim, Min
AU - Jacob, Ninan
AU - Ashfaq, Yusuf
AU - Kroeger, Zachary
AU - Zhang, Micheal
AU - Chotcomwongse, Peranut
AU - Ruamviboonsuk, Paisan
AU - Winter, Halit
AU - Gill, Manjot
AU - Lima, Luiz H.
AU - Wu, Lihteh
AU - Chhablani, Jay
AU - Vupparaboina, Kiran K.
AU - Zarnegar, Arman
AU - Yiu, Glenn
AU - Wang, Jay
AU - Vujosevic, Stela
AU - Villafeurte, Carol
AU - Sobrin, Lucia
AU - Small, Kent
AU - Singhanetr, Panisa
AU - Silva, Rufino
AU - Shah, Priya
AU - Sahoo, Niroj Kumar
AU - Rossin, Elizabeth
AU - Rodriguez, Francisco
AU - Pili, Lorenzo
AU - Piccoli, Gabriele
AU - Parodi, Maurizio Battaglia
AU - Ni, Roselind
AU - Munk, Marion R.
AU - Momenaei, Bita
AU - Lupidi, Marco
AU - Lai, Timothy
AU - Koizumi, Hideki
AU - Khurana, Rahul N.
AU - Imanaga, Naoya
AU - Hertkorn, Felicia
AU - Gregori, Giulia
AU - Garg, Sunir
AU - Doshi, Utkarsh
AU - Gadari, Adarsh
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
PY - 2026/1
Y1 - 2026/1
N2 - Purpose: While central serous chorioretinopathy (CSCR) frequently resolves after the first episode, in 30–50% of cases, subretinal fluid (SRF) persists and can substantially impair vision. To identify persistence predictors, this study compared demographic, clinical, and imaging data between patients with resolution and SRF persistence. Methods: Retrospective data were collected at baseline and follow-up from 308 eyes of 295 patients with CSCR in collaboration with the Macula Society CSCR Study Group. Patients were divided into a resolved (RG) and a persistent CSCR group (PG). Patients with known recurrence after resolution were excluded. Optical coherence tomography (OCT) biomarkers including central macular thickness (CMT), subfoveal choroidal thickness (SFCT), neurosensory detachment height (NSD), Haller layer thickness, inner choroidal thickness (ICT), and choroidal vascularity index (CVI) were analysed. Results: PG had 148 eyes and RG had 160 eyes. Mean age in PG vs RG was 47.62 ± 11.63 vs. 44.89 ± 10.12 years (p = 0.029). Mean presenting symptom duration was significantly greater in PG than RG (8.67 ± 23.33 vs. 4.33 ± 31.18 months) (p = 0.005). There was a higher frequency of complex cases (21.6%) in PG (p < 0.001). Baseline mean CMT (358.11 ± 157.02 microns) and NSD height (175.78 ± 134.34 microns) were significantly lower in PG (p = 0.007). Multivariate logistic regression analysis showed that each additional year of age was associated with a 22.3% increase in the odds of having persistent SRF. Conclusion: Age at presentation, symptom duration, baseline CMT and NSD height may serve as practical risk stratifiers to identify eyes at high risk for chronicity in CSCR. Key messages: What is known Delayed presentation and absence of early therapy predispose eyes to chronic CSCR. SFCT plays a predictive role in persistent CSCR. What is new Age at presentation is a significant predictor of persistent SRF. Baseline CMT and NSD height may serve as practical risk stratifiers to identify eyes at high risk for chronicity.
AB - Purpose: While central serous chorioretinopathy (CSCR) frequently resolves after the first episode, in 30–50% of cases, subretinal fluid (SRF) persists and can substantially impair vision. To identify persistence predictors, this study compared demographic, clinical, and imaging data between patients with resolution and SRF persistence. Methods: Retrospective data were collected at baseline and follow-up from 308 eyes of 295 patients with CSCR in collaboration with the Macula Society CSCR Study Group. Patients were divided into a resolved (RG) and a persistent CSCR group (PG). Patients with known recurrence after resolution were excluded. Optical coherence tomography (OCT) biomarkers including central macular thickness (CMT), subfoveal choroidal thickness (SFCT), neurosensory detachment height (NSD), Haller layer thickness, inner choroidal thickness (ICT), and choroidal vascularity index (CVI) were analysed. Results: PG had 148 eyes and RG had 160 eyes. Mean age in PG vs RG was 47.62 ± 11.63 vs. 44.89 ± 10.12 years (p = 0.029). Mean presenting symptom duration was significantly greater in PG than RG (8.67 ± 23.33 vs. 4.33 ± 31.18 months) (p = 0.005). There was a higher frequency of complex cases (21.6%) in PG (p < 0.001). Baseline mean CMT (358.11 ± 157.02 microns) and NSD height (175.78 ± 134.34 microns) were significantly lower in PG (p = 0.007). Multivariate logistic regression analysis showed that each additional year of age was associated with a 22.3% increase in the odds of having persistent SRF. Conclusion: Age at presentation, symptom duration, baseline CMT and NSD height may serve as practical risk stratifiers to identify eyes at high risk for chronicity in CSCR. Key messages: What is known Delayed presentation and absence of early therapy predispose eyes to chronic CSCR. SFCT plays a predictive role in persistent CSCR. What is new Age at presentation is a significant predictor of persistent SRF. Baseline CMT and NSD height may serve as practical risk stratifiers to identify eyes at high risk for chronicity.
KW - CMT
KW - NSD
KW - OCT
KW - Persistent CSCR
UR - https://www.scopus.com/pages/publications/105018642303
UR - https://www.scopus.com/inward/citedby.url?scp=105018642303&partnerID=8YFLogxK
U2 - 10.1007/s00417-025-06969-5
DO - 10.1007/s00417-025-06969-5
M3 - Article
C2 - 41074999
AN - SCOPUS:105018642303
SN - 0721-832X
VL - 264
SP - 73
EP - 80
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 1
ER -