Predictors of locoregional recurrence among patients with early-stage breast cancer treated with breast-conserving therapy

Nadeem Q. Mirza, Georges Vlastos, Funda Meric, Thomas A. Buchholz, Nestor Esnaola, S. Eva Singletary, Henry M. Kuerer, Lisa A. Newman, Frederick C. Ames, Merrick I. Ross, Barry W. Feig, Raphael E. Pollock, Marsha McNeese, Eric Strom, Kelly K. Hunt

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

Background: Our aim was to identify predictors of locoregional recurrence (LRR) in patients with early-stage breast cancer treated with breast-conserving therapy (BCT) and long-term follow-up. Methods: From 1970 to 1994, 1153 patients with stage I to II breast cancer underwent BCT and radiotherapy at our institution. Patients with prior breast cancer or other primary malignancies were excluded. Clinical and pathologic characteristics evaluated were age, race, tumor size, stage, pathologic tumor margins, axillary nodal involvement, estrogen and progesterone receptor status, Black's nuclear grade, type of surgery, and use of adjuvant therapy. Results: Of 1083 patients, 54% presented with stage I disease and 46% with stage II disease. Median age was 50 years, and median follow-up was 9 years. Axillary nodes were positive in 31% of the patients who underwent axillary dissection. LRR developed in 6%, LRR followed by systemic recurrence in 5%, and systemic recurrence alone in 13%; 76% had no evidence of recurrence at last follow-up. Age, tumor size, positive lymph nodes, and not receiving chemotherapy or hormonal therapy were independent predictors of LRR. Disease-specific survival among patients with LRR was similar to that among patients with no recurrence. Conclusions: Multidisciplinary treatment strategies should be used to accomplish durable locoregional control after BCT.

Original languageEnglish (US)
Pages (from-to)256-265
Number of pages10
JournalAnnals of Surgical Oncology
Volume9
Issue number3
DOIs
StatePublished - 2002

Keywords

  • Breast neoplasms
  • Breast-conserving therapy
  • Local recurrence
  • Predictors
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

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