TY - JOUR
T1 - Predictors of impulsivity and reward seeking behavior with dopamine agonists
AU - Ondo, William G.
AU - Lai, Dejian
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/1
Y1 - 2008/1
N2 - Three hundred consecutive patients taking DA either for Parkinson's disease (PD, 207), restless legs syndrome (RLS, 89), or both (4) were interviewed about changes in gambling, spending, sexual activity, or other impulsive activities subsequent to DA. Regression models identified risk factors for impulsivity. Overall, 19.7% reported any increased impulsivity: 30 gambling, 26 spending, 11 sexual activity, and 1 wanton traveling. Only 11/59 felt the change was deleterious. Increased impulsivity correlated with a younger age (p=0.01), larger doses of DA (p<0.001), and PD, as opposed to RLS (p<0.01), but this lost significance after correcting for dose (p=0.09). Increased impulsivity is common but usually not deleterious.
AB - Three hundred consecutive patients taking DA either for Parkinson's disease (PD, 207), restless legs syndrome (RLS, 89), or both (4) were interviewed about changes in gambling, spending, sexual activity, or other impulsive activities subsequent to DA. Regression models identified risk factors for impulsivity. Overall, 19.7% reported any increased impulsivity: 30 gambling, 26 spending, 11 sexual activity, and 1 wanton traveling. Only 11/59 felt the change was deleterious. Increased impulsivity correlated with a younger age (p=0.01), larger doses of DA (p<0.001), and PD, as opposed to RLS (p<0.01), but this lost significance after correcting for dose (p=0.09). Increased impulsivity is common but usually not deleterious.
KW - Dopamine agonist
KW - Gambling
KW - Parkinson's disease
KW - Restless legs syndrome
KW - Reward mechanism
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U2 - 10.1016/j.parkreldis.2007.05.006
DO - 10.1016/j.parkreldis.2007.05.006
M3 - Article
C2 - 17702628
AN - SCOPUS:38349168959
SN - 1353-8020
VL - 14
SP - 28
EP - 32
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 1
ER -