TY - JOUR
T1 - Predictors of chronic kidney disease in long-term survivors of lung and heart-lung transplantation
AU - Canales, M.
AU - Youssef, P.
AU - Spong, R.
AU - Ishani, A.
AU - Savik, K.
AU - Hertz, M.
AU - Ibrahim, H. N.
PY - 2006/9
Y1 - 2006/9
N2 - Renal insufficiency is common after non-renal organ transplants. The predictors of long-term renal outcomes are not well established. A total of 219 lung and heart-lung transplant recipients surviving more than 6 months after transplantation were studied to determine predictors of time to doubling of serum creatinine and end-stage kidney disease (ESKD) with death as a competing risk. Median follow-up was 79 months (range 9-222 months). Baseline estimated glomerular filtration rate (GFR) was 96.3 ± 34.5 mL/min/1.73 m2. One hundred twenty-two recipients (55%) doubled their serum creatinine, 16 (7.3%) progressed to ESKD and 143 (65%) died. The majority of recipients who survived >6 years had a GFR < 60 mL/min at both 1 and 7 years. Most of the loss of renal function occurred in the first year post-transplant. Older age at transplant, lower GFR at 1 month and cyclosporine use in the first 6 months predicted shorter time to doubling of serum creatinine when death was handled as a competing risk. Based on this prevalence data and using GFR decay and death as study endpoints, we offer sample size estimates for a prospective, interventional trial that is aimed at slowing or preventing the progression of kidney disease.
AB - Renal insufficiency is common after non-renal organ transplants. The predictors of long-term renal outcomes are not well established. A total of 219 lung and heart-lung transplant recipients surviving more than 6 months after transplantation were studied to determine predictors of time to doubling of serum creatinine and end-stage kidney disease (ESKD) with death as a competing risk. Median follow-up was 79 months (range 9-222 months). Baseline estimated glomerular filtration rate (GFR) was 96.3 ± 34.5 mL/min/1.73 m2. One hundred twenty-two recipients (55%) doubled their serum creatinine, 16 (7.3%) progressed to ESKD and 143 (65%) died. The majority of recipients who survived >6 years had a GFR < 60 mL/min at both 1 and 7 years. Most of the loss of renal function occurred in the first year post-transplant. Older age at transplant, lower GFR at 1 month and cyclosporine use in the first 6 months predicted shorter time to doubling of serum creatinine when death was handled as a competing risk. Based on this prevalence data and using GFR decay and death as study endpoints, we offer sample size estimates for a prospective, interventional trial that is aimed at slowing or preventing the progression of kidney disease.
KW - Chronic kidney disease
KW - Heart-lung transplantation
KW - Long-term survivors
KW - Lung transplantation
UR - http://www.scopus.com/inward/record.url?scp=33746863330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746863330&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2006.01458.x
DO - 10.1111/j.1600-6143.2006.01458.x
M3 - Article
C2 - 16827787
AN - SCOPUS:33746863330
VL - 6
SP - 2157
EP - 2163
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 9
ER -