Predictive and Prognostic Roles of Gut Microbial Variation in Liver Transplant

Hon Jen Wong, Wen Hui Lim, Cheng Han Ng, Darren Jun Hao Tan, Glenn K. Bonney, Alfred W.C. Kow, Daniel Q. Huang, Mohammad Shadab Siddiqui, Mazen Noureddin, Nicholas Syn, Mark D. Muthiah

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Patients undergoing liver transplant (LTX) typically confront a challenging postoperative journey. A dysbiotic gut microbiome is associated with the development of complications, including post-LTX allograft rejection, metabolic diseases and de novo or recurrent cancer. A major explanation of this are the bipartite interactions between the gut microbiota and host immunity, which modulates the alloimmune response towards the liver allograft. Furthermore, bacterial translocation from dysbiosis causes pathogenic changes in the concentrations of microbial metabolites like lipopolysaccharides, short-chain fatty acids (SCFAs) and Trimethylamine-N-Oxide, with links to cardiovascular disease development and diabetes mellitus. Gut dysbiosis also disrupts bile acid metabolism, with implications for various post-LTX metabolic diseases. Certain taxonomy of microbiota such as lactobacilli, F.prausnitzii and Bacteroides appear to be associated with these undesired outcomes. As such, an interesting but as yet unproven hypothesis exists as to whether induction of a “beneficial” composition of gut microbiota may improve prognosis in LTX patients. Additionally, there are roles of the microbiome as predictive and prognostic indicators for clinicians in improving patient care. Hence, the gut microbiome represents an exceptionally exciting avenue for developing novel prognostic, predictive and therapeutic applications.

Original languageEnglish (US)
Article number873523
JournalFrontiers in Medicine
StatePublished - May 10 2022


  • cancer
  • gut microbiome
  • immunity
  • liver transplantation
  • metabolic disease
  • prevention
  • rejection

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Predictive and Prognostic Roles of Gut Microbial Variation in Liver Transplant'. Together they form a unique fingerprint.

Cite this