Prediction of tumor response to endocrine therapy in prostatic carcinoma based on steroid receptor assay.

P. Ekman, Jan-Ake Gustafsson, B. Högberg, A. Pousette, M. Snochowski

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Measurement of estrogen receptor content in human breast cancer has become a valuable tool to predict the response of a tumor to endocrine manipulations. The aim of this study was to see whether steroid receptor assay could also be used to predict the value of endocrine therapy in human prostatic carcinoma. Biopsies from 25 primary tumors were analyzed with regard to quantity of methyltrienolone (a synthetic androgen) binding to the receptor 20 specimens were receptor-positive and 5 were receptor-negative. The correlation between receptor content and response to endocrine treatment was approximately approximately equal to 80%. The steroid receptor profiles of 5 lymph node metastases were also analyzed. 4/5 contained methyltrienolone receptors and 2/5 contained progestin receptors. 3/5 were glucocorticoid receptor-positive while all specimens were estrogen receptor-negative.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalScandinavian Journal of Urology and Nephrology, Supplement
Volume55
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Nephrology
  • Urology

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