Prediction of Significant Conduction Disease through Noninvasive Assessment of Cardiac Calcification

Sumeet K. Mainigi, Lakshmi Hima Bindu Chebrolu, Abel Romero-Corral, Vinay Mehta, Rodolfo Rozindo MacHado, Tomas Konecny, Gregg S. Pressman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Aims: Cardiac calcification is associated with coronary artery disease, arrhythmias, conduction disease, and adverse cardiac events. Recently, we have described an echocardiographic-based global cardiac calcification scoring system. The objective of this study was to evaluate the severity of cardiac calcification in patients with permanent pacemakers as based on this scoring system. Methods and Results: Patients with a pacemaker implanted within the 2-year study period with a previous echocardiogram were identified and underwent blinded global cardiac calcium scoring. These patients were compared to matched control patients without a pacemaker who also underwent calcium scoring. The study group consisted of 49 patients with pacemaker implantation who were compared to 100 matched control patients. The mean calcium score in the pacemaker group was 3.3 ± 2.9 versus 1.8 ± 2.0 (P = 0.006) in the control group. Univariate and multivariate analysis revealed glomerular filtration rate and calcium scoring to be significant predictors of the presence of a pacemaker. Conclusion: Echocardiographic-based calcium scoring correlates with the presence of severe conduction disease requiring a pacemaker.

Original languageEnglish (US)
Pages (from-to)1017-1021
Number of pages5
Issue number9
StatePublished - Oct 2012


  • calcification
  • calcium
  • conduction disease
  • heart block
  • pacemaker

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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