Prediction of post-transplant graft survival by different definitions of early allograft dysfunction

Tao Luo, Shu Jiao He, Shi Rui Chen, Tie Long Wang, Chang Jun Huang, Dong Ping Wang, Wei Qiang Ju, Qiang Zhao, Mao Gen Chen, Ying Hua Chen, An Bin Hu, Yi Ma, Guo Dong Wang, Xiao Feng Zhu, Shun Wei Huang, Zhi Yong Guo, Xiao Shun He

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The efficacy of early allograft dysfunction (EAD) definitions in predicting post-transplant graft survival in a Chinese population is still unclear. Methods: A total of 607 orthotopic liver transplants (OLT) have been included in the current study. Model accuracy was evaluated using receiver operating characteristic (ROC) analysis. Risk factors for EAD was evaluated using univariable analysis and multivariable logistic regression model. Results: The 3-, 6-, and 12-month patient/graft survival were 91.6%/91.4%, 91.1%/90%, and 87.5%/87.3%, respectively. MELDPOD5 had a superior discrimination of 3-month graft survival (C statistic, 0.83), compared with MEAF (C statistic, 0.77) and Olthoff criteria (C statistic, 0.72). Multivariate analysis of risk factors for EAD defined by MELDPOD5, showed that donor body mass index (P=0.001), donor risk index (P=0.006), intraoperative use of packed red blood cells (P=0.001), hypertension of recipient (P=0.004), and preoperative total bilirubin (P<0.001) were independent risk factors. Conclusions: The results suggest that MLEDPOD5 is a better criterion of EAD for the Chinese population, which might serve as a surrogate end-point for graft survival in clinical study.

Original languageEnglish (US)
Pages (from-to)8584-8595
Number of pages12
JournalAnnals of Palliative Medicine
Volume10
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • Early allograft dysfunction (EAD)
  • Graft survival
  • Patient survival

ASJC Scopus subject areas

  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

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