@article{d7bd74d98db74b2496a58e239344727d,
title = "Prediction of post-transplant graft survival by different definitions of early allograft dysfunction",
abstract = "Background: The efficacy of early allograft dysfunction (EAD) definitions in predicting post-transplant graft survival in a Chinese population is still unclear. Methods: A total of 607 orthotopic liver transplants (OLT) have been included in the current study. Model accuracy was evaluated using receiver operating characteristic (ROC) analysis. Risk factors for EAD was evaluated using univariable analysis and multivariable logistic regression model. Results: The 3-, 6-, and 12-month patient/graft survival were 91.6%/91.4%, 91.1%/90%, and 87.5%/87.3%, respectively. MELDPOD5 had a superior discrimination of 3-month graft survival (C statistic, 0.83), compared with MEAF (C statistic, 0.77) and Olthoff criteria (C statistic, 0.72). Multivariate analysis of risk factors for EAD defined by MELDPOD5, showed that donor body mass index (P=0.001), donor risk index (P=0.006), intraoperative use of packed red blood cells (P=0.001), hypertension of recipient (P=0.004), and preoperative total bilirubin (P<0.001) were independent risk factors. Conclusions: The results suggest that MLEDPOD5 is a better criterion of EAD for the Chinese population, which might serve as a surrogate end-point for graft survival in clinical study.",
keywords = "Early allograft dysfunction (EAD), Graft survival, Patient survival",
author = "Tao Luo and He, {Shu Jiao} and Chen, {Shi Rui} and Wang, {Tie Long} and Huang, {Chang Jun} and Wang, {Dong Ping} and Ju, {Wei Qiang} and Qiang Zhao and Chen, {Mao Gen} and Chen, {Ying Hua} and Hu, {An Bin} and Yi Ma and Wang, {Guo Dong} and Zhu, {Xiao Feng} and Huang, {Shun Wei} and Guo, {Zhi Yong} and He, {Xiao Shun}",
note = "Funding Information: Funding: This work was supported by grants as follows: the National Natural Science Foundation of China (82070670 and 81970564), the Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People{\textquoteright}s Republic of China, the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology (2013A061401007, 2017B030314018), the Natural Science Foundations of Guangdong province (2016A030310141), Guangdong Provincial international Cooperation Base of Science and Technology (Organ Transplantation) (2015B050501002), Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project (2015A030308010), Guangdong Provincial Natural Science Funds for Distinguished Young Scholars (2015A030306025), Special support program for training high level talents in Guangdong Province (2015TQ01R168), Science and Technology Program of Guangzhou (201704020150), Science and Technology Program of Guangdong (2020B1111140003), Sun Yat-sen University Young Teacher Key Cultivate Project (17ykzd29), “Elite program” specially supported by China organ transplantation development foundation and Natural Science Foundation of Guangdong Province (2016A030313239). Funding Information: This work was supported by grants as follows: the National Natural Science Foundation of China (82070670 and 81970564), the Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People?s Republic of China, the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology (2013A061401007, 2017B030314018), the Natural Science Foundations of Guangdong province (2016A030310141), Guangdong Provincial international Cooperation Base of Science and Technology (Organ Transplantation) (2015B050501002), Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project (2015A030308010), Guangdong Provincial Natural Science Funds for Distinguished Young Scholars (2015A030306025), Special support program for training high level talents in Guangdong Province (2015TQ01R168), Science and Technology Program of Guangzhou (201704020150), Science and Technology Program of Guangdong (2020B1111140003), Sun Yat-sen University Young Teacher Key Cultivate Project (17ykzd29), ?Elite program? specially supported by China organ transplantation development foundation and Natural Science Foundation of Guangdong Province (2016A030313239). Publisher Copyright: {\textcopyright} Annals of Palliative Medicine. All rights reserved.",
year = "2021",
month = aug,
doi = "10.21037/apm-21-1012",
language = "English (US)",
volume = "10",
pages = "8584--8595",
journal = "Annals of Palliative Medicine",
issn = "2224-5820",
publisher = "AME Publishing Company",
number = "8",
}