Predicting progression to AIDS: An evaluation of two approaches

Linda Rabeneck; Pamela M. Hartigan; Iris W. Huang; Julianne Souchek; Nelda P. Wray

doi:10.1007/bf02599030

Predicting progression to AIDS: An evaluation of two approaches

Linda Rabeneck, Pamela M. Hartigan, Iris W. Huang, Julianne Souchek, Nelda P. Wray

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This study evaluated the predictive validity of two clinical staging systems for HIV infection (the Rabeneck and Royce systems) using data obtained from the Department of Veterans Affairs Cooperative Study Number 298, a randomized clinical trial involving 335 symptomatic patients with CD4 counts of 200 to 500/mm³. The relation between the HIV clinical stages and progression to AIDS was examined using Kaplan-Meier estimates, and Cox models were used to determine if the stages remained predictive after controlling for CD4 count. Both systems were significant independent predictors of progression to AIDS. This work demonstrates that simple, valid staging systems for HIV infection can be developed that provide greater prognostic distinction than the CD4 count alone.

Original language	English (US)
Pages (from-to)	622-624
Number of pages	3
Journal	Journal of General Internal Medicine
Volume	11
Issue number	10
DOIs	https://doi.org/10.1007/bf02599030
State	Published - 1996

Keywords

AIDS
CD4 count
HIV Clinical staging systems
human immunodeficiency virus (HIV)
predicting HIV outcomes

ASJC Scopus subject areas

Internal Medicine

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10.1007/bf02599030

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title = "Predicting progression to AIDS: An evaluation of two approaches",

abstract = "This study evaluated the predictive validity of two clinical staging systems for HIV infection (the Rabeneck and Royce systems) using data obtained from the Department of Veterans Affairs Cooperative Study Number 298, a randomized clinical trial involving 335 symptomatic patients with CD4 counts of 200 to 500/mm3. The relation between the HIV clinical stages and progression to AIDS was examined using Kaplan-Meier estimates, and Cox models were used to determine if the stages remained predictive after controlling for CD4 count. Both systems were significant independent predictors of progression to AIDS. This work demonstrates that simple, valid staging systems for HIV infection can be developed that provide greater prognostic distinction than the CD4 count alone.",

keywords = "AIDS, CD4 count, HIV Clinical staging systems, human immunodeficiency virus (HIV), predicting HIV outcomes",

author = "Linda Rabeneck and Hartigan, {Pamela M.} and Huang, {Iris W.} and Julianne Souchek and Wray, {Nelda P.}",

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AU - Rabeneck, Linda

AU - Hartigan, Pamela M.

AU - Huang, Iris W.

AU - Souchek, Julianne

AU - Wray, Nelda P.

PY - 1996

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AB - This study evaluated the predictive validity of two clinical staging systems for HIV infection (the Rabeneck and Royce systems) using data obtained from the Department of Veterans Affairs Cooperative Study Number 298, a randomized clinical trial involving 335 symptomatic patients with CD4 counts of 200 to 500/mm3. The relation between the HIV clinical stages and progression to AIDS was examined using Kaplan-Meier estimates, and Cox models were used to determine if the stages remained predictive after controlling for CD4 count. Both systems were significant independent predictors of progression to AIDS. This work demonstrates that simple, valid staging systems for HIV infection can be developed that provide greater prognostic distinction than the CD4 count alone.

KW - AIDS

KW - CD4 count

KW - HIV Clinical staging systems

KW - human immunodeficiency virus (HIV)

KW - predicting HIV outcomes

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Predicting progression to AIDS: An evaluation of two approaches

Abstract

Keywords

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