Predicting outcomes in HIV-infected veterans: II. Survival after AIDS

Linda Rabeneck, Pamela M. Hartigan, Iris W. Huang, Julianne Souchek, Nelda Wray

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

This article (Part II) and the preceding article (Part I) report the development of two clinical staging systems for HIV-infected individuals. The objective of The research reported here (Part II) was to construct a clinical staging system to predict survival in patients with AIDS. We analyzed data from VA Cooperative Study Number 298, a multicenter, double-blind, randomized trial that compared immediate versus deferred zidovudine therapy in HIV-infected individuals. Baseline variables obtained at the onset of AIDS in 204 individuals were tested in univariate Cox regression for their relationship to survival, and those that appeared predictive were examined in multivariable analysis. Based on these analyses, we constructed a new AIDS Clinical Staging System. The system is based on age, CD4+ cell count, type of first AIDS-defining condition, and functional status. The stages of the system were significant predictors of survival (p = 0.0001, log-rank test). In conclusion, valid, simple clinical staging systems for patients with AIDS can be developed based on a few variables that are readily available in clinical settings.

Original languageEnglish (US)
Pages (from-to)1241-1248
Number of pages8
JournalJournal of Clinical Epidemiology
Volume50
Issue number11
DOIs
StatePublished - Nov 1997

Keywords

  • Acquired immunodeficiency syndrome
  • HIV
  • Prognosis
  • Severity of illness index

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

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