TY - JOUR
T1 - Predicting outcomes in HIV-infected veterans
T2 - I. Progression to AIDS
AU - Rabeneck, Linda
AU - Hartigan, Pamela M.
AU - Huang, Iris W.
AU - Souchek, Julianne
AU - Wray, Nelda
N1 - Funding Information:
Supported by the Department of Veterans Affairs, Veterans Health Administration, Health Services Research and DeveIoptnent (HSR&?D) Service (Project IIR #@l-030). Dr. Rabeneck is the recipient of a Department of Veterans Affairs Career Development Award.
PY - 1997/11
Y1 - 1997/11
N2 - This article and the following article (Parts I and II) report the development of two clinical staging systems for HIV-infected individuals: The objective of the research reported here (Part I) was to construct a clinical staging system to predict progression to AIDS. We analysed data from VA Cooperative Study Number 298, a multicenter, double-blind, randomized trial that compared immediate versus deferred zidovudine therapy in 338 HIV-infected individuals who did not have AIDS at enrollment. Baseline variables were tested in univariate Cox regression for their relationship to progression to AIDS, and those that appeared predictive were examined in multivariable analysis. Based on these analyses, we constructed a new clinical staging system based on CD4+ cell count, age, hemoglobin, oral hairy leukoplakia or oral thrush, and fever. The stages of the system were significant predictors of progression to AIDS (p = 0.0001, log-rank test). In conclusion, simple, valid, clinical staging systems for HIV infected patients can be constructed using information that is readily available in clinical practice settings. Such systems provide better prognostic distinction than CD4+ cell count alone by taking into account the known prognostic effects of other variables.
AB - This article and the following article (Parts I and II) report the development of two clinical staging systems for HIV-infected individuals: The objective of the research reported here (Part I) was to construct a clinical staging system to predict progression to AIDS. We analysed data from VA Cooperative Study Number 298, a multicenter, double-blind, randomized trial that compared immediate versus deferred zidovudine therapy in 338 HIV-infected individuals who did not have AIDS at enrollment. Baseline variables were tested in univariate Cox regression for their relationship to progression to AIDS, and those that appeared predictive were examined in multivariable analysis. Based on these analyses, we constructed a new clinical staging system based on CD4+ cell count, age, hemoglobin, oral hairy leukoplakia or oral thrush, and fever. The stages of the system were significant predictors of progression to AIDS (p = 0.0001, log-rank test). In conclusion, simple, valid, clinical staging systems for HIV infected patients can be constructed using information that is readily available in clinical practice settings. Such systems provide better prognostic distinction than CD4+ cell count alone by taking into account the known prognostic effects of other variables.
KW - Acquired immunodeficiency syndrome
KW - HIV
KW - Prognosis
KW - Severity of illness index
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U2 - 10.1016/S0895-4356(97)00181-9
DO - 10.1016/S0895-4356(97)00181-9
M3 - Article
C2 - 9393379
AN - SCOPUS:0030728170
SN - 0895-4356
VL - 50
SP - 1231
EP - 1240
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 11
ER -