Precision Nutrition Model Predicts Glucose Control of Overweight Females following the Consumption of Potatoes High in Resistant Starch

Joy V. Nolte Fong, Derek Miketinas, Linda W. Moore, Duc T. Nguyen, Edward A. Graviss, Nadim Ajami, Mindy A. Patterson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive equations are needed to provide personalized dietary recommendations to reduce chronic disease development. Therefore, a precision nutrition model pre-dicting the postprandial glucose response (PPGR) in overweight women following the consumption of potatoes was formulated. Thirty overweight women participated in this randomized crossover trial. Participants consumed 250 g of hot (9.2 g RS) or cold (13.7 g RS) potatoes on two separate occasions. Baseline characteristics included demographics, 10-day dietary records, body composition, and the relative abundance (RA) and α-diversity of gut microbiota. Elastic net regression using 5-fold cross-validation predicted PPGR after potato intake. Most participants (70%) had a favorable PPGR to the cold potato. The model explained 32.2% of the variance in PPGR with the equation: 547.65 × (0 [if cold, high-RS potato], ×1, if hot, low-RS potato]) + (BMI [kg/m2 ] × 40.66)—(insoluble fiber [g] × 49.35) + (Bacteroides [RA] × 8.69)—(Faecalibacterium [RA] × 73.49)—(Parabacteroides [RA] × 42.08) + (α-diversity × 110.87) + 292.52. This model improves the understanding of baseline characteristics that explain interpersonal variation in PPGR following potato intake and offers a tool to optimize dietary recommendations for a commonly consumed food.

Original languageEnglish (US)
Article number268
Issue number2
StatePublished - Jan 9 2022


  • Faecalibacterium
  • Microbiome
  • Potatoes
  • Precision nutrition
  • Resistant starch
  • Body Mass Index
  • Area Under Curve
  • Glycemic Index
  • Blood Glucose/metabolism
  • Humans
  • Gastrointestinal Microbiome
  • Vegetables/chemistry
  • Cross-Over Studies
  • Young Adult
  • Solanum tuberosum/chemistry
  • Diet
  • Models, Biological
  • Resistant Starch/pharmacology
  • Postprandial Period
  • Obesity/blood
  • Adult
  • Female
  • Overweight/blood
  • Nutritional Status

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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