Precision medicine at the academic-industry interface

Patrick J. Silva, Kenneth S. Ramos

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Precision medicine, and specifically the test-then-treat paradigm, have been common practice in medicine for over a century. Recent advances in high-throughput omics, notably next-generation sequencing, have enabled resolution of clinically actionable differences at the molecular level and facilitated greater understanding of human pathogenesis at the individual population scales. These new analytic technologies, coupled with a growing number of therapeutic agents designed to target specific molecules, has catalyzed the transition of treatment modalities from anatomically/pathologically defined interventions, to algorithm-based treatments, rooted on molecularly defined endpoints. Underlying the bifurcated population health-molecular disease perspective is the capability to curate highly granular clinical data, at the case level and throughout the lifecycle of disease. Academic medical centers are at the forefront of developing infrastructure to interface with these challenges, and are thus, a focal point of industry engagement, in the development and validation of precision medicine technology, products, and decision rules.

Original languageEnglish (US)
Title of host publicationPrecision Medicine for Investigators, Practitioners and Providers
PublisherElsevier
Pages545-560
Number of pages16
ISBN (Electronic)9780128191781
DOIs
StatePublished - Jan 1 2019

Keywords

  • Biobanks
  • Biological specimens
  • Clinical trials
  • Drug development
  • Gene patent
  • Genome sequencing
  • Molecular biomarkers
  • Probe patent
  • Reverse translation study
  • cDNA patent

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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