Precision management of coronary in-stent restenosis

Travis M. Wilson; Panagiotis M. Sarris-Michopoulos; Riyan Siddiqui; Adeel Ahmed; Iqra Riaz; Giancarlo Licitra; Julia Ossi; Muzamil Khawaja; Alexander C. Fanaroff; Akiko Maehara; Davide Capodanno; Chayakrit Krittanawong

doi:10.1016/j.tcm.2025.07.009

Precision management of coronary in-stent restenosis

Travis M. Wilson, Panagiotis M. Sarris-Michopoulos, Riyan Siddiqui, Adeel Ahmed, Iqra Riaz, Giancarlo Licitra, Julia Ossi, Muzamil Khawaja, Alexander C. Fanaroff, Akiko Maehara, Davide Capodanno, Chayakrit Krittanawong

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The advent of percutaneous coronary intervention (PCI) and intracoronary stent development marked a pivotal milestone in the management of acute coronary syndromes, significantly reducing morbidity and mortality worldwide. However, despite ongoing advancements in stent technology, treatment modalities, and diagnostic tools, in-stent restenosis (ISR) remains a prevalent and challenging clinical issue, contributing substantially to the burden of cardiovascular disease. This review provides a comprehensive background of ISR, including its associated risk factors, pathophysiology, and current management strategies. By addressing gaps in ISR management, this review critically evaluates existing approaches and explores potential directions for advancing the field of interventional cardiology. Additionally, supporting data for these strategies are examined, and a diagnostic and treatment algorithm is proposed to guide complex clinical decision-making.

Original language	English (US)
Pages (from-to)	44-55
Number of pages	12
Journal	Trends in Cardiovascular Medicine
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.tcm.2025.07.009
State	Published - Jan 2026

Keywords

Coronary artery disease
In stent restenosis
Percutaneous coronary intervention

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.tcm.2025.07.009

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title = "Precision management of coronary in-stent restenosis",

abstract = "The advent of percutaneous coronary intervention (PCI) and intracoronary stent development marked a pivotal milestone in the management of acute coronary syndromes, significantly reducing morbidity and mortality worldwide. However, despite ongoing advancements in stent technology, treatment modalities, and diagnostic tools, in-stent restenosis (ISR) remains a prevalent and challenging clinical issue, contributing substantially to the burden of cardiovascular disease. This review provides a comprehensive background of ISR, including its associated risk factors, pathophysiology, and current management strategies. By addressing gaps in ISR management, this review critically evaluates existing approaches and explores potential directions for advancing the field of interventional cardiology. Additionally, supporting data for these strategies are examined, and a diagnostic and treatment algorithm is proposed to guide complex clinical decision-making.",

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doi = "10.1016/j.tcm.2025.07.009",

language = "English (US)",

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AU - Wilson, Travis M.

AU - Sarris-Michopoulos, Panagiotis M.

AU - Siddiqui, Riyan

AU - Ahmed, Adeel

AU - Riaz, Iqra

AU - Licitra, Giancarlo

AU - Ossi, Julia

AU - Khawaja, Muzamil

AU - Fanaroff, Alexander C.

AU - Maehara, Akiko

AU - Capodanno, Davide

AU - Krittanawong, Chayakrit

PY - 2026/1

Y1 - 2026/1

N2 - The advent of percutaneous coronary intervention (PCI) and intracoronary stent development marked a pivotal milestone in the management of acute coronary syndromes, significantly reducing morbidity and mortality worldwide. However, despite ongoing advancements in stent technology, treatment modalities, and diagnostic tools, in-stent restenosis (ISR) remains a prevalent and challenging clinical issue, contributing substantially to the burden of cardiovascular disease. This review provides a comprehensive background of ISR, including its associated risk factors, pathophysiology, and current management strategies. By addressing gaps in ISR management, this review critically evaluates existing approaches and explores potential directions for advancing the field of interventional cardiology. Additionally, supporting data for these strategies are examined, and a diagnostic and treatment algorithm is proposed to guide complex clinical decision-making.

AB - The advent of percutaneous coronary intervention (PCI) and intracoronary stent development marked a pivotal milestone in the management of acute coronary syndromes, significantly reducing morbidity and mortality worldwide. However, despite ongoing advancements in stent technology, treatment modalities, and diagnostic tools, in-stent restenosis (ISR) remains a prevalent and challenging clinical issue, contributing substantially to the burden of cardiovascular disease. This review provides a comprehensive background of ISR, including its associated risk factors, pathophysiology, and current management strategies. By addressing gaps in ISR management, this review critically evaluates existing approaches and explores potential directions for advancing the field of interventional cardiology. Additionally, supporting data for these strategies are examined, and a diagnostic and treatment algorithm is proposed to guide complex clinical decision-making.

KW - Coronary artery disease

KW - In stent restenosis

KW - Percutaneous coronary intervention

UR - https://www.scopus.com/pages/publications/105012041161

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U2 - 10.1016/j.tcm.2025.07.009

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AN - SCOPUS:105012041161

SN - 1050-1738

VL - 36

SP - 44

EP - 55

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 1

ER -

Precision management of coronary in-stent restenosis

Abstract

Keywords

ASJC Scopus subject areas

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