TY - JOUR
T1 - Precision design of engineered nanomaterials to guide immune systems for disease treatment
AU - Li, Jiulong
AU - Gao, Xingfa
AU - Wang, Yuguang
AU - Xia, Tian
AU - Zhao, Yuliang
AU - Meng, Huan
N1 - Funding Information:
The authors acknowledge financial support from the National Key Research and Development Program of China ( 2021YFA1200902 ), the Strategic Priority Research Program of the Chinese Academy of Sciences ( XDB36000000 ), and the start-up funding support from the National Center for Nanoscience and Technology , Chinese Academy of Sciences ( CAS ) ( E1763911 ).
Funding Information:
The authors acknowledge financial support from the National Key Research and Development Program of China (2021YFA1200902), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB36000000), and the start-up funding support from the National Center for Nanoscience and Technology, Chinese Academy of Sciences (CAS) (E1763911). Conceptualization, J.L. T.X. Y.Z. and H.M.; investigation, J.L.; writing ? original draft, J.L.; writing ? review & editing, J. L. X.G. Y.W. T.X. Y.Z. and H.M.; funding acquisition, H.M.; supervision, H.M. The authors declare no competing interests.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/4/6
Y1 - 2022/4/6
N2 - Engineered nanomaterials (ENMs) are widely used in industrial, commercial, and medical fields due to their unique physicochemical properties and diverse functional advantages. Human exposure or direct contact with ENMs via various routes, including dermal, inhalation, and systemic administration, may allow ENMs to interact with immune systems, leading to immunostimulation or immunosuppression outcomes depending on antigen properties. The actions of various immunological responses and how ENMs' intrinsic properties impact immune responses are fascinating but under-investigated. Herein, we systemically review state-of-the-art advances in various molecular mechanisms of ENM-induced immunological responses to outline the critical roles of material properties on immunity. Through the growing awareness of nano quantitative structure-activity relationship (QSAR), we further conceptualize how to utilize ENMs’ immunomodulatory properties to develop safe, precise, and effective immunomodulation strategies based on high throughput and predictive discovery paradigms. We also discuss the challenges and opportunities for clinical translation using nano-enabled immune modulation for disease treatment.
AB - Engineered nanomaterials (ENMs) are widely used in industrial, commercial, and medical fields due to their unique physicochemical properties and diverse functional advantages. Human exposure or direct contact with ENMs via various routes, including dermal, inhalation, and systemic administration, may allow ENMs to interact with immune systems, leading to immunostimulation or immunosuppression outcomes depending on antigen properties. The actions of various immunological responses and how ENMs' intrinsic properties impact immune responses are fascinating but under-investigated. Herein, we systemically review state-of-the-art advances in various molecular mechanisms of ENM-induced immunological responses to outline the critical roles of material properties on immunity. Through the growing awareness of nano quantitative structure-activity relationship (QSAR), we further conceptualize how to utilize ENMs’ immunomodulatory properties to develop safe, precise, and effective immunomodulation strategies based on high throughput and predictive discovery paradigms. We also discuss the challenges and opportunities for clinical translation using nano-enabled immune modulation for disease treatment.
KW - computational design
KW - immunostimulation
KW - immunosuppression
KW - immunotherapy
KW - nano QSAR
KW - nano-immune interaction
KW - nanomaterials
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U2 - 10.1016/j.matt.2022.03.005
DO - 10.1016/j.matt.2022.03.005
M3 - Review article
AN - SCOPUS:85127482481
VL - 5
SP - 1162
EP - 1191
JO - Matter
JF - Matter
SN - 2590-2393
IS - 4
ER -